ArticleEvidence-based complementary and alternative medicine : eCAM2011
Antimetastatic Potentials of Dioscorea nipponica on Melanoma In Vitro and In Vivo.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Antimetastatic Potential of Garcinone E in Human Oral Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2019Article
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- Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.Experimental and therapeutic medicine · 2017Article
- Weighted Gene Co-expression Network Analysis of the Dioscin Rich Medicinal PlantFrontiers in plant science · 2017Article
- By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer.Oncotarget · 2015Article
- Article
- Corrigendum to "Antimetastatic Potentials of Dioscorea nipponica on Melanoma In Vitro and In Vivo".Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines.Archives of toxicology · 2013Article
- Specific Dioscorea Phytoextracts Enhance Potency of TCL-Loaded DC-Based Cancer Vaccines.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Reversion of p-glycoprotein-mediated multidrug resistance in human leukemic cell line by diallyl trisulfide.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Autophagy inhibition enhances apoptosis induced by dioscin in huh7 cells.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Therapeutic Effect of Total Saponins from Dioscorea nipponica Makino on Gouty Arthritis Based on the NF-κB Signal Pathway: An In vitro Study.Pharmacognosy magazineArticle
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have revealed pleiotropic anticancer and antiproliferative capabilities of Dioscorea nipponica Makino whereas the effect of this plant on metastasis of cancer cells has not been clearly clarified. In the present study, we extracted Dioscorea nipponica Makino with methanol (DNE1), chloroform (DNE2), ethyl acetate (DNE3), n-butanol (DNE4), and water (DNE5). We first demonstrate that DNE3 was found to be effective in reducing the lung metastases formation by about 99.5% as compared to vehicle-treated control animals. When a nontoxic concentration of the extract was treated directly to highly metastatic murin melanoma cells (B16F10) and human melanoma cells (A2058) in vitro, it exerted a dose-dependent inhibitory effect on the invasion (P < .001), motility (P < .001), secretion of MMPs (P < .001), and u-PA (P < .001) of both cell lines. To investigate the possible mechanisms involved in these events, we performed western blot analysis to find that DNE inhibited phosphorylation of Akt. A treatment with DNE3 to B16F10 cells also inhibited the activation of NF-κB and increased the expression of IkappaB. Taken together, these findings suggested that DNE3 could reduce the metastasis of melanoma cells, thereby constituting an adjuvant treatment for metastasis control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.