Evidence map›Paper›PMID 21274375›Full record

ArticleWorld journal of gastroenterology2011

Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis.

David Philippe, Laurent Favre, Francis Foata, Oskar Adolfsson, Genevieve Perruisseau-Carrier, Karine Vidal, Gloria Reuteler, Johanna Dayer-Schneider, Christoph Mueller, Stéphanie Blum

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Nutrients · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. MaternalFASEB bioAdvances · 2022
    Article
  11. Article
  12. Article
  13. Synbiotic Effect ofNutrients · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David PhilippeDepartment of Nutrition and Health, Nestlé Research Centre, Vers-chez-les-Blanc, Lausanne 26, Switzerland. david.philippe@rdls.nestle.com
Laurent Favre
Francis Foata
Oskar Adolfsson
Genevieve Perruisseau-Carrier
Karine Vidal
Gloria Reuteler
Johanna Dayer-Schneider
Christoph Mueller
Stéphanie Blum

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis.

methodsDonor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice.

resultsAll recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis.

conclusionDaily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.

Indexed as

Adoptive TransferAnimalsBifidobacteriumBiomarkersBody WeightColitisDisease Models, AnimalFecesHumansInflammationMiceMice, Inbred C57BLProbioticsT-LymphocytesBiomarkersAdoptive transfer modelBifidobacteriumColitisInflammationMiceProbioticsRegulatory T cells

Identifiers

PMID21274375
PMCPMC3027012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.