ArticleJournal of clinical research in pediatric endocrinology2010
Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods.
Article in Journal of clinical research in pediatric endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 158 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence and Risk Factors of Insulin Resistance in Overweight and Obese Adolescents
A Non-Invasive Diagnostic Panel for MASLD in Children With Obesity: Evaluation of a Multiparametric Biomarker Panel and Genetic Risk Score Using LASSO-Regularized Logistic Regression - The PedMASLD-MultiOmics Pilot Study
Who cites it
158 citing papers in PubMed, 3 syntheses or guidelines pooled it, 303 citations in OpenAlex.
- Combined aerobic and resistance exercise improves glucose metabolism and insulin resistance in children and adolescents with overweight or obesity: a meta-analysis.Scientific reports · 2026Pooled it
- Reference Curves for Metabolic Syndrome Indicators in Children and Adolescents: A Global Systematic Review.Current obesity reports · 2026Pooled it
- [Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2016Pooled it
- Trial
- Subclinical cardiac alterations and cardiometabolic profile in adolescents with newly diagnosed polycystic ovary syndrome: A cross-sectional comparative echocardiographic study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Inflammation and polyendocrine metabolic ovarian syndrome: utilizing proteomics to unravel this link in adolescents.Journal of the Endocrine Society · 2026Article
- Fasting Biomarkers and Glycated Haemoglobin Identify Children With Excess Weight at Risk of Dysglycaemia and Guide Oral Glucose Tolerance Testing.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Evaluation of Early Diagnostic Methods for Subclinical Cardiovascular Changes in Childhood Obesity.Medeniyet medical journal · 2026Article
- Systemic inflammatory indices and glucose homeostasis in children with obesity: evidence from oral glucose tolerance testing.European journal of pediatrics · 2026Article
- Association of Waist Circumference and Body Composition Indices with Insulin Resistance in Prepubertal Children with Obesity.Metabolites · 2026Article
- Evaluation of aquaporin-7, adiponectin, and TNF-α levels in obese children.Journal of endocrinological investigation · 2026Article
- Article
- Body Weight and Insulin Resistance Indicators Among Children.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Screening and diagnosis of metabolic dysfunction-associated steatotic liver disease in children within public healthcare.Pediatric research · 2026Article
- 20/ (fasting C-peptide × fasting plasma glucose) as a novel marker for insulin resistance in obese children and adolescents.Pediatric research · 2026Article
- Age-related changes in METS-IR and HOMA-IR in obese adults and their relationship with cardiometabolic comorbidities.Archives of endocrinology and metabolism · 2026Article
- Children born small-for-gestational-age exhibit normal body fat but elevated hs-CRP and hepatocellular lipid content.Pediatric research · 2026Article
- Neck circumference is associated with metabolic syndrome parameters in adolescents with obesity: a cross-sectional study.BMC pediatrics · 2026Article
- Associations of systemic inflammatory indices and metabolically healthy vs. unhealthy obesity in children.Italian journal of pediatrics · 2026Article
- Article
98 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChildhood obesity is associated with an increased risk for insulin resistance. The underlying mechanism for the physiological increase in insulin levels in puberty is not clearly understood. The aim of the present study was to determine the cut-off values for homeostasis model assessment for insulin resistance (HOMA-IR) in obese children and adolescents according to gender and pubertal status.
methodsTwo hundred and eight obese children and adolescents (141 girls, 127 boys) aged between 5 and 18 years were included in the study. The children were divided into prepubertal and pubertal groups. A standard oral glucose tolerance test (OGTT) was carried out in all children. A total insulin level exceeding 300 μU/mL in the blood samples, collected during the test period, was taken as the insulin resistance criterion. Cut-off values for HOMA-IR were calculated by receiver operating characteristic (ROC) analysis.
resultsIn the prepubertal period, the rate of insulin resistance was found to be 37% in boys and 27.8% in girls,while in the pubertal period, this rate was 61.7% in boys and 66.7% in girls. HOMA-IR cut-off values for insulin resistance in the prepubertal period were calculated to be 2.67 (sensitivity 88.2%, specificity 65.5%) in boys and 2.22 (sensitivity 100%, specificity 42.3%) in girls, and in the pubertal period, they were 5.22 (sensitivity 56%, specificity 93.3%) in boys and 3.82 (sensitivity 77.1%, specificity 71.4%) in girls.
conclusionsSince gender, obesity and pubertal status are factors affecting insulin resistance, cut-off values which depend on gender and pubertal status, should be used in evaluation of insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.