ArticleEye (London, England)2011
Visual perceptions induced by intravitreous injections of therapeutic agents.
Article in Eye (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Optical imaging and spectroscopic characterization of subvisible particles in protein therapeutics.Advanced drug delivery reviews · 2026Review
- Assessment of Subjective Visual Experiences During Intraocular Surgery and Intravitreal Injection Among Uveitis Patients at a Tertiary Eye Hospital: A Cross-Sectional Observational Study.Ophthalmology and therapy · 2026Article
- Subjective and objective measures of the patient experience before, during, and after intravitreal anti-vascular endothelial growth factor injections.Indian journal of ophthalmology · 2021Observational
- A Strategy for Personalized Treatment of iPS-Retinal Immune Rejections Assessed in Cynomolgus Monkey Models.International journal of molecular sciences · 2020Article
- Visual perceptions induced by intravitreal injections.Eye (London, England) · 2012Article
- Delivery of intraocular triamcinolone acetonide in the treatment of macular edema.Pharmaceutics · 2012Article
- Evaluation of patients' experiences at different stages of the intravitreal injection procedure - what can be improved?Clinical ophthalmology (Auckland, N.Z.) · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to conduct a questionnaire-based survey of subjective visual perceptions induced by intravitreous (IVT) injections of therapeutic agents. PATIENTS AND
methodsPatients undergoing an IVT injection of ranibizumab, pegaptanib sodium, or triamcinolone acetonide were administered a questionnaire in the immediate post-injection period and at 2 weeks of follow-up.
resultsIn the immediate post-injection period (75 IVT injections, 75 eyes, 75 patients), lights and floaters were reported after 20 (27%) and 24 (32%) IVT injections, respectively. In comparison, at the 2-week follow-up, the incidence of reported lights (11; 15%) was similar (P>0.05), but the incidence of reported floaters was higher (48; 64%; P=0.00). Subgroup analysis for various injection subgroups (no previous injection vs previous injection(s) in the study eye; injections in study eyes with good VA (logarithm of minimal angle of resolution [logMAR] ≤ 0.3) vs moderate VA (0.7 <logMAR>0.3) vs poor VA (logMAR ≥ 0.7); injections according to pharmacological agent (ranibizumab vs pegaptanib vs triamcinolone acetonide); injections in study eyes with choroidal neovascularization (of various causes) vs study eyes with macular edema (of various causes); and injections in phakic vs pseudophakic eyes) did not reveal any statistically significant associations. Visual perceptions experienced following 15% of IVT injections gave cause for concern to the patient (mean visual analog scale score (± SD): 4.5 (± 1.7)), and in 64% of cases, the patients believed that preoperative counseling would have averted the concern.
conclusionsLights and floaters are frequent visual perceptions following IVT injections of therapeutic agents. They can give rise to concern that could be alleviated with preinjection counseling.
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