ArticleJournal of perinatology : official journal of the California Perinatal Association2011
Association of necrotizing enterocolitis with anemia and packed red blood cell transfusions in preterm infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 79 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Infants
Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates.
Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis
Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 196 citations in OpenAlex.
- Association of anemia and necrotizing enterocolitis in neonates: Systematic review and meta-analysis of transfusion thresholds, erythropoietin trials, and observational studies.Journal of neonatal-perinatal medicine · 2026Pooled it
- Hematological parameters of bronchopulmonary dysplasia in preterm infants: a meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Risk factors for necrotizing enterocolitis in preterm infants: a Meta analysis.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Pooled it
- Erythropoietin prevents necrotizing enterocolitis in very preterm infants: a randomized controlled trial.Journal of translational medicine · 2020Trial
- Trial
- The role of myeloid cells in the pathogenesis of necrotizing enterocolitis; a scoping review.Frontiers in pediatrics · 2026Review
- Development and validation of a nomogram model for predicting the occurrence of necrotizing enterocolitis in premature infants with late-onset sepsis.European journal of medical research · 2025Article
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Article
- Evaluation of gestational age, serum amyloid A, and hemoglobin decline (ΔHb) as diagnostic markers for NEC secondary to late-onset sepsis in preterm infants.Frontiers in pediatrics · 2025Article
- Risk factors for necrotizing enterocolitis in small-for-gestational-age infants: a matched case-control study.Scientific reports · 2024Article
- RBC transfusion and necrotizing enterocolitis in very preterm infants: a multicenter observational study.Scientific reports · 2024Observational
- [Research progress on the relationship between anemia and neonatal necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Gestational age-specific hematological features in preterm infants with necrotizing enterocolitis.Pediatric research · 2024Article
- [Predictive value of hemoglobin decrease for necrotizing enterocolitis in preterm infants with late-onset sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Transfusion-associated necrotising enterocolitis in very low birth weight babies: transfusion and feeding practices in two neonatal units in Bloemfontein, Free State.The Southern African journal of critical care : the official journal of the Critical Care Society · 2024Article
- Clinical Dilemma Involving Treatments for Very Low-Birth-Weight Infants and the Potential Risk of Necrotizing Enterocolitis: A Narrative Literature Review.Journal of clinical medicine · 2023Review
- Red Blood Cell Transfusion, Anemia, Feeding, and the Risk of Necrotizing Enterocolitis.Clinics in perinatology · 2023Review
- Observational
- Necrotizing enterocolitis: recent advances in treatment with translational potential.Pediatric surgery international · 2023Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine association of anemia and red blood cell (RBC) transfusions with necrotizing enterocolitis (NEC) in preterm infants. STUDY
designA total of 111 preterm infants with NEC ≥ stage 2a were compared with 222 matched controls. In all, 28 clinical variables, including hematocrit (Hct) and RBC transfusions were recorded. Propensity scores and multivariate logistic regression models were created to examine effects on the risk of NEC.
resultControlling for other factors, lower Hct was associated with increased odds of NEC (odds ratio (OR)=1.10, P=0.01). RBC transfusion has a temporal relationship with NEC onset. Transfusion within 24 h (OR=7.60, P=0.001) and 48 h (OR=5.55, P=0.001) has a higher odds of developing NEC but this association is not significant by 96 h (OR=2.13, P=0.07), post-transfusion.
conclusionAnemia may increase the risk of developing NEC in preterm infants. RBC transfusions are temporally related to NEC. Prospective studies are needed to better evaluate the potential influence of transfusions on the development of NEC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.