ArticleThe Pediatric infectious disease journal2011
Immunogenicity of trivalent influenza vaccine in extremely low-birth-weight, premature versus term infants.
Article in The Pediatric infectious disease journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Age-dependent immune landscapes affect influenza vaccine effectiveness and guide precision strategies.Frontiers in immunology · 2026Review
- Vaccination in preterm and low birth weight infants in India.Human vaccines & immunotherapeutics · 2022Review
- Vaccination experiences of premature children in a retrospective hospital-based cohort in a Chinese metropolitan area.Human vaccines & immunotherapeutics · 2021Article
- Article
- Differences in Influenza-Specific CD4 T-Cell Mediated Immunity Following Acute Infection Versus Inactivated Vaccination in Children.The Journal of infectious diseases · 2021Article
- Influenza in Children.Cold Spring Harbor perspectives in medicine · 2021Review
- Differential gene expression in peripheral blood mononuclear cells from children immunized with inactivated influenza vaccine.Human vaccines & immunotherapeutics · 2020Article
- The Importance of Vaccinating Children and Pregnant Women against Influenza Virus Infection.Pathogens (Basel, Switzerland) · 2019Review
- Plasma cell and serum antibody responses to influenza vaccine in preterm and full-term infants.Vaccine · 2017Article
- The TLR-specific adjuvants R-848 and CpG-B endorse the immunological reaction of neonatal antigen-presenting cells.Pediatric research · 2016Article
- Preterm Birth during Influenza Season Is Associated with Adverse Outcome in Very Low Birth Weight Infants.Frontiers in pediatrics · 2016Article
- Immunization of preterm infants.Human vaccines & immunotherapeutics · 2015Review
- Influenza vaccination in children at high risk of respiratory disease.Therapeutic advances in vaccines · 2013Article
- Memory CD8+ T cells are sufficient to alleviate impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementation.Clinical and vaccine immunology : CVI · 2012Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundInfluenza vaccine immunogenicity in premature infants is incompletely characterized.
objectiveTo assess the immunogenicity of trivalent, inactivated influenza vaccine (TIV) in extremely low-birth-weight (≤ 1000 g birth weight) premature (<30 weeks gestation) infants. We hypothesized that geometric mean titers of influenza antibody would be lower in premature than in full-term (FT) (≥ 37 week) infants. DESIGN/
methodsIn this prospective multicenter study, former premature and FT infants who were 6 to 17 months of age received 2 doses of TIV during the 2006-2007 or 2007-2008 influenza seasons. Sera were drawn before dose 1, and 4 to 6 weeks after dose 2. Antibody was measured by hemagglutination inhibition.
resultsOver 2 years, 41 premature and 42 FT infants were enrolled; 36 and 33 of these infants, respectively, had postvaccination titers available. Premature infants weighed less (mean, 1.3-1.8 kg difference) at the time of immunization than FT infants. Prevaccination titers did not differ between groups. Premature infants had higher postvaccination antibody geometric mean titers than FT infants to H1 (2006-2007, 1:513 vs. 1:91, P = 0.03; 2007-2008, 1:363 vs. 1:189, P = 0.02) and B/Victoria (2006-2007, 1:51 vs. 1:10, P = 0.02). More premature than FT infants had antibody titers ≥ 1:32 to B/Victoria (85% vs. 60%, P = 0.04) in 2007-2008. Two (5%) premature and 8 (19%) FT infants had adverse events, primarily fever, within 72 hours after vaccination. No child had medically diagnosed influenza.
conclusionsFormer premature infants had antibody responses to 2 TIV doses higher than or equal to those of FT children. Two TIV doses are immunogenic and well tolerated in extremely low-birth-weight, premature infants 6 to 17 months old.
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