Trial reportNeurosurgery2011
Weight changes in subthalamic nucleus vs globus pallidus internus deep brain stimulation: results from the COMPARE Parkinson disease deep brain stimulation cohort.
Trial report in Neurosurgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Trial
- Active electrode location does not influence weight gain after subthalamic nucleus deep brain stimulation surgery in Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Weight and survival after deep brain stimulation for Parkinson's disease.Parkinsonism & related disorders · 2023Article
- Mechanisms and consequences of weight gain after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease.Scientific reports · 2023Article
- Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.Neurobiology of disease · 2021Article
- The Thermodynamic Consequences of Parkinson's Disease.Frontiers in neurology · 2021Review
- Weight Change After Subthalamic Nucleus Deep Brain Stimulation in Patients With Isolated Dystonia.Frontiers in neurology · 2021Article
- Review
- Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Body weight gain in patients with bilateral deep brain stimulation for dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity.NeuroImage. Clinical · 2015Review
- Update on deep brain stimulation in Parkinson's disease.Translational neurodegeneration · 2015Article
- The "brittle response" to Parkinson's disease medications: characterization and response to deep brain stimulation.PloS one · 2014Article
- Mechanisms of body weight fluctuations in Parkinson's disease.Frontiers in neurology · 2014Review
- Stereotactic surgery for eating disorders.Surgical neurology international · 2013Article
- Weight change after globus pallidus internus or subthalamic nucleus deep brain stimulation in Parkinson's disease and dystonia.Stereotactic and functional neurosurgery · 2012Article
- Comparison of weight changes following unilateral and staged bilateral STN DBS for advanced PD.Brain and behavior · 2011Article
- Challenges in PD Patient Management After DBS: A Pragmatic Review.Movement disorders clinical practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundParkinson's patients, on average, gain weight after deep brain stimulation (DBS).
objectiveTo determine potential differences in weight gain when comparing the subthalamic nucleus and the globus pallidus internus target.
methodsA retrospective analysis was performed on the prospective, randomized cohort of National Institutes of Health COMPARE trial DBS patients who received unilateral subthalamic nucleus or globus pallidus internus DBS. Baseline weights were recorded before DBS surgery and at 6, 12, and 18 months postoperatively. Relationships between weight change and changes in Beck Depression Inventory score, Unified Parkinson's Disease Rating Scale (UPDRS) motor score (part III) (also the dyskinesia duration and disability subscores from UPDRS IV), and Hoehn-Yahr stage were determined via Spearman's rank-order correlation coefficients. Regression analyses were performed to investigate the effects of potential factors on weight change over time.
resultsPatients in the COMPARE DBS cohort gained a significant amount of weight, a mean of 4.86 lb (standard deviation = 8.73) (P = .001), but there was no significant difference between subthalamic nucleus and globus pallidus internus targets (weight gain of 4.29 ± 6.79 and 5.38 ± 10.32 lb, respectively; P = .68). Weight gain did not correlate with Beck Depression Inventory score change, UPDRS motor score, dyskinesia duration, dyskinesia disability change, or the Hoehn-Yahr stage (P = .62, .21, and .31, respectively). No specific variable was associated with weight gain, and there were no differences in binge eating post-surgery in either target.
conclusionThere were significant changes in weight over time after DBS therapy. However, neither Beck Depression Inventory score change nor UPDRS score change or dyskinesia was correlated with weight gain. No significant factor was associated with the weight change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.