ReviewJournal of genetics2010
Application of RNA interference in treating human diseases.
Review in Journal of genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Constructing the boundary between potent and ineffective siRNAs by MG-algorithm with C-features.BMC bioinformatics · 2022Article
- miRNA‑504 inhibits p53‑dependent vascular smooth muscle cell apoptosis and may prevent aneurysm formation.Molecular medicine reports · 2017Article
- Aberrant Expression of microRNA-9 Contributes to Development of Intracranial Aneurysm by Suppressing Proliferation and Reducing Contractility of Smooth Muscle Cells.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Progress and Prospects of Anti-HBV Gene Therapy Development.International journal of molecular sciences · 2015Review
- Delivery and targeting of miRNAs for treating liver fibrosis.Pharmaceutical research · 2015Review
- Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing.Molecular and cellular biology · 2015Article
- A preliminary step of a novel strategy in suicide gene therapy with lentiviral vector.Advanced biomedical research · 2014Article
- Circulating microRNA: a novel potential biomarker for early diagnosis of intracranial aneurysm rupture a case control study.Journal of translational medicine · 2013Article
- RNA viruses and microRNAs: challenging discoveries for the 21st century.Physiological genomics · 2013Review
- Replacement of all arginine residues with canavanine in MazF-bs mRNA interferase changes its specificity.The Journal of biological chemistry · 2013Article
- A novel lentivirus for quantitative assessment of gene knockdown in stem cell differentiation.Gene therapy · 2012Review
- RNA interference: A futuristic tool and its therapeutic applications.Saudi journal of biological sciences · 2012Article
- MicroRNA expression signature in human abdominal aortic aneurysms.BMC medical genomics · 2012Article
- Selection of RNAi-based inhibitors for anti-HIV gene therapy.World journal of virology · 2012Review
- Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells.Inflammation · 2012Article
- VIRsiRNAdb: a curated database of experimentally validated viral siRNA/shRNA.Nucleic acids research · 2012Article
- Sonoporation using microbubbles promotes lipofectamine-mediated siRNA transduction to rat retina.Bosnian journal of basic medical sciences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene silencing can occur either through repression of transcription, termed transcriptional gene silencing (TGS), or through translation repression andmRNA degradation, termed posttranscriptional gene silencing (PTGS). PTGS results from sequence-specific mRNA degradation in the cytoplasm without dramatic changes in transcription of corresponding gene in nucleus. Both TGS and PTGS are used to regulate endogenous genes. Interestingly, mechanisms for gene silencing also protect the genome from transposons and viruses. In this paper, we first review RNAi mechanism and then focus on some of its applications in biomedical research such as treatment for HIV, viral hepatitis, cardiovascular and cerebrovascular diseases, metabolic disease, neurodegenerative disorders and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.