ArticleAnticancer research2011
Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival.
Article in Anticancer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Additive effect of Ruta graveolens bioactive phytoconstituents and cisplatin through PKC/MEK/ERK pathway in glioblastoma.Molecular therapy. Oncology · 2026Article
- Pharmaco-Toxicological Effects ofAntioxidants (Basel, Switzerland) · 2025Article
- Ethyl acetate extract ofFrontiers in pharmacology · 2025Article
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- Traditional Uses, Phytochemistry, Pharmacology and Toxicology ofDrug design, development and therapy · 2024Review
- Review
- Furanocoumarins fromMolecules (Basel, Switzerland) · 2021Article
- Clonogenic Assays to Detect Cell Fate in Mitotic Catastrophe.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Current Progress of Phytomedicine in Glioblastoma Therapy.Current medical science · 2020Review
- Imperatorin as a Promising Chemotherapeutic Agent Against Human Larynx Cancer and Rhabdomyosarcoma Cells.Molecules (Basel, Switzerland) · 2020Article
- Silver Nanoparticle Production byBioinorganic chemistry and applications · 2020Article
- Chalepin: A Compound fromPharmacognosy magazine · 2017Article
- Decatropis bicolor (Zucc.) Radlk essential oil induces apoptosis of the MDA-MB-231 breast cancer cell line.BMC complementary and alternative medicine · 2016Article
- Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.Molecules (Basel, Switzerland) · 2015Article
- Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21.Molecules (Basel, Switzerland) · 2015Article
- Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation.PloS one · 2015Article
- Integrative nanomedicine: treating cancer with nanoscale natural products.Global advances in health and medicine · 2014Review
- Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells.Anticancer research · 2012Article
- Cystic swelling and inflammation of MCL of knee joint managed with homeopathy; a case study with literature review and diagnostic pitfalls.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRuta graveolens is a medicinal herb that has been used for centuries against various ailments. This study examined the anticancer properties of the herb using cancer cell lines. MATERIALS AND
methodsMethanolic extract of R. graveolens was tested on colon, breast and prostate cancer cells. Viability, cell cycle profiles, clonogenicity and capase activation were measured. Induction and subcellular localizations of p53, 53BP1 and γ-H2AX proteins were examined.
resultsThe extract dose-dependently decreased the viability and the clonogenicity of treated cells and induced G₂/M arrest, aberrant mitoses, and caspase-3 activation. It also induced the p53 pathway and focal concentration of the DNA damage response proteins 53BP1 and γ-H2AX. Moreover, the levels of phospho-Akt and cyclin B1 were reduced by treatment, whereas only cyclin B1 was reduced in normal dermal fibroblasts.
conclusionR. graveolens extract contains bioactive compounds which, independently of known photoactivatable mechanisms, potently inhibit cancer cell proliferation and survival through multiple targets.
Indexed as
Identifiers
21273604PMC3124362W2099310077What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.