ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.
- The role of acetazolamide in sleep apnea at sea level: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Pooled it
- Prediction of cardiopulmonary events using the STOP-Bang questionnaire in patients undergoing bronchoscopy with moderate sedation.Scientific reports · 2020Trial
- Predictive factors for sleep apnoea in patients on opioids for chronic pain.BMJ open respiratory research · 2019Trial
- Continuous Positive Airway Pressure Mitigates Opioid-induced Worsening of Sleep-disordered Breathing Early after Bariatric Surgery.Anesthesiology · 2016Trial
- Partially countering the physiological effects of fentanyl with naloxone or d-cysteine ethyl ester in adult goats.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- A wearable acoustofluidic patch for rapid reversal of opioid overdose.Nature communications · 2026Article
- The role of carotid bodies in opioid-induced respiratory depression.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Divergent ventilatory responses during opioid-induced respiratory depression in response to repeated fentanyl use.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Article
- CBPharmacological research · 2025Article
- Naloxone reversal of the cardiorespiratory depressant effects of opioids and mixtures of opioids and stimulants in rats.Frontiers in pharmacology · 2025Article
- Asymmetric neuromodulation in the respiratory network contributes to rhythm and pattern generation.Frontiers in neural circuits · 2025Article
- Article
- Pharmacological modulation of respiratory control: Ampakines as a therapeutic strategy.Pharmacology & therapeutics · 2025Review
- Sudden Death Induced by Acute Inhalation of Aerosolized Carfentanil.Archives of clinical and biomedical research · 2025Article
- The Effect of Opioids and Benzodiazepines on Exacerbation Rate and Overall Survival in Patients with Chronic Obstructive Pulmonary Disease on Long-Term Non-Invasive Ventilation.Journal of clinical medicine · 2024Article
- Human IPSC-Derived PreBötC-Like Neurons and Development of an Opiate Overdose and Recovery Model.Advanced biology · 2024Article
- Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Opioids in Treatment of Refractory Dyspnea in Chronic Obstructive Pulmonary Disease: Yes, No or Maybe.Journal of personalized medicine · 2024Review
- Latent neural population dynamics underlying breathing, opioid-induced respiratory depression and gasping.Nature neuroscience · 2024Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The analgesic properties of the opium poppy Papever somniferum were first mentioned by Hippocrates around 400 BC, and opioid analgesics remain the mainstay of pain management today. These drugs can cause the serious side-effect of respiratory depression that can be lethal with overdose, however the critical brain sites and neurochemical identity of the neurons mediating this depression are unknown. By locally manipulating neurotransmission in the adult rat, we identify the critical site of the medulla, the preBötzinger complex, that mediates opioid-induced respiratory depression in vivo. Here we show that opioids at the preBötzinger complex cause respiratory depression or fatal apnea, with anesthesia and deep-sleep being particularly vulnerable states for opioid-induced respiratory depression. Importantly, we establish that the preBötzinger complex is fully responsible for respiratory rate suppression following systemic administration of opioid analgesics. The site in the medulla most sensitive to opioids corresponds to a region expressing neurokinin-1 receptors, and we show in rhythmically active brainstem section in vitro that neurokinin-1 receptor-expressing preBötzinger complex neurons are selectively inhibited by opioids. In summary, neurokinin-1 receptor-expressing preBötzinger complex neurons constitute the critical site mediating opioid-induced respiratory rate depression, and the key therapeutic target for its prevention or reversal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.