ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
The mouse cochlea expresses a local hypothalamic-pituitary-adrenal equivalent signaling system and requires corticotropin-releasing factor receptor 1 to establish normal hair cell innervation and cochlear sensitivity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Lateral olivocochlear neurons modulate cochlear responses to noise exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular and functional profiling of cell diversity and identity in the lateral superior olive, an auditory brainstem center with ascending and descending projections.Frontiers in cellular neuroscience · 2024Article
- Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system.eLife · 2023Article
- Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss.International journal of molecular sciences · 2023Article
- A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023Review
- Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea.iScience · 2022Article
- G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss.Frontiers in molecular neuroscience · 2022Review
- Cochlear Fibrocyte and Osteoblast Lineages Expressing Type 2 Deiodinase Identified with a Dio2CreERt2 Allele.Endocrinology · 2021Article
- Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition.Frontiers in neural circuits · 2021Article
- Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift.The Journal of physiology · 2019Article
- Spatial Gradients in the Size of Inner Hair Cell Ribbons Emerge Before the Onset of Hearing in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- No longer falling on deaf ears: mechanisms of degeneration and regeneration of cochlear ribbon synapses.Hearing research · 2015Review
- Cellular signaling protective against noise-induced hearing loss – A role for novel intrinsic cochlear signaling involving corticotropin-releasing factor?Biochemical pharmacology · 2015Review
- Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life.Cell and tissue research · 2015Review
- Key role of CRF in the skin stress response system.Endocrine reviews · 2013Review
- Contralateral-noise effects on cochlear responses in anesthetized mice are dominated by feedback from an unknown pathway.Journal of neurophysiology · 2012Article
- The cochlea as an independent neuroendocrine organ: expression and possible roles of a local hypothalamic-pituitary-adrenal axis-equivalent signaling system.Hearing research · 2012Review
- Stress and tinnitus-from bedside to bench and back.Frontiers in systems neuroscience · 2012Article
- The cochlear CRF signaling systems and their mechanisms of action in modulating cochlear sensitivity and protection against trauma.Molecular neurobiology · 2011Review
- Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing.The Journal of biological chemistry · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cells of the inner ear face constant metabolic and structural stress. Exposure to intense sound or certain drugs destroys cochlea hair cells, which in mammals do not regenerate. Thus, an endogenous stress response system may exist within the cochlea to protect it from everyday stressors. We recently described the existence of corticotropin-releasing factor (CRF) in the mouse cochlea. The CRF receptor type 1 (CRFR1) is considered the primary and canonical target of CRF signaling, and systemically it plays an essential role in coordinating the body-wide stress response via activation of the hypothalamic-pituitary-adrenal (HPA) axis. Here, we describe an essential role for CRFR1 in auditory system development and function, and offer the first description of a complete HPA equivalent signaling system resident within the cochlea. To reveal the role of CRFR1 activation in the cochlea, we have used mice carrying a null ablation of the CRFR1 gene. CRFR1(-/-) mice exhibited elevated auditory thresholds at all frequencies tested, indicating reduced sensitivity. Furthermore, our results suggest that CRFR1 has a developmental role affecting inner hair cell morphology and afferent and efferent synapse distribution. Given the role of HPA signaling in maintaining local homeostasis in other tissues, the presence of a cochlear HPA signaling system suggests important roles for CRFR1 activity in setting cochlear sensitivity, perhaps both neural and non-neural mechanisms. These data highlight the complex pleiotropic mechanisms modulated by CRFR1 signaling in the cochlea.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.