ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Functional connectome of the striatal medium spiny neuron.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.
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Who cites it
170 citing papers in PubMed.
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- Suppression of haptoglobin and loss of striatal neurons in mice chronically exposed to chlorpyrifos-contaminated drinking water.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- How the dynamic interplay of cortico-basal ganglia-thalamic pathways shapes the time course of deliberation and commitment.PLoS computational biology · 2026Article
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- Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dopamine and serotonin cotransmission filters striatonigral synaptic activity via 5-HT1B receptor activation.Science advances · 2025Article
- The songbird basal ganglia connectome.bioRxiv : the preprint server for biology · 2025Article
- A Celsr3 Mutation Linked to Tourette Disorder Disrupts Cortical Dendritic Patterning and Striatal Cholinergic Interneuron Excitability.International journal of molecular sciences · 2025Article
- Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Characterization of GαiScience · 2025Article
- Neurotrophins and Their Receptors: BDNF's Role in GABAergic Neurodevelopment and Disease.International journal of molecular sciences · 2024Review
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- A transdiagnostic and translational framework for delineating the neuronal mechanisms of compulsive exercise in anorexia nervosa.The International journal of eating disorders · 2024Review
- Globus pallidus is not independent from striatal direct pathway neurons: an up-to-date review.Molecular brain · 2024Review
- Computational insights on asymmetricalCognitive neurodynamics · 2024Article
- Pathological cell assembly dynamics in a striatal MSN network model.Frontiers in computational neuroscience · 2024Article
- The Interactions of Temporal and Sensory Representations in the Basal Ganglia.Advances in experimental medicine and biology · 2024Review
- Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia.Frontiers in cellular neuroscience · 2024Article
110 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
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Abstract
Dopamine system disorders ranging from movement disorders to addiction and schizophrenia involve striatal medium spiny neurons (MSNs), yet their functional connectivity has been difficult to determine comprehensively. We generated a mouse with conditional channelrhodopsin-2 expression restricted to medium spiny neurons and assessed the specificity and strength of their intrinsic connections in the striatum and their projections to the globus pallidus and the substantia nigra. In the striatum, medium spiny neurons connected with other MSNs and tonically active cholinergic interneurons, but not with fast-spiking GABA interneurons. In the globus pallidus, medium spiny neurons connected strongly with one class of electrophysiologically identified neurons, but weakly with the other. In the substantia nigra, medium spiny neurons connected strongly with GABA, but not with dopamine neurons. Projections to the globus pallidus showed solely D2-mediated presynaptic inhibition, whereas projections to the substantia nigra showed solely D1-mediated presynaptic facilitation. This optogenetic approach defines the functional connectome of the striatal medium spiny neuron.
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