ArticleVeterinary microbiology2011
Isolation of an equine coronavirus from adult horses with pyrogenic and enteric disease and its antigenic and genomic characterization in comparison with the NC99 strain.
Article in Veterinary microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- Fecal virome at the human-animal interface: a one health perspective on an uncharted frontier.Animal microbiome · 2026Review
- First serological evidence of equine coronavirus and severe acute respiratory syndrome coronavirus 2 in horses in North Africa.Veterinary research communications · 2025Article
- The first outbreak of equine coronavirus infection in 13 years among draft horses at Obihiro Racecourse in Japan in 2025.The Journal of veterinary medical science · 2025Article
- Article
- Investigation of the seroprevalence to equine coronavirus and SARS-CoV-2 in healthy adult horses recently imported to the United States.The veterinary quarterly · 2024Article
- Equine coronavirus infection and replication in equine intestinal enteroids.Veterinary research · 2024Article
- Human Challenge Studies with Coronaviruses Old and New.Current topics in microbiology and immunology · 2024Review
- Presence of Equine and Bovine Coronaviruses, Endoparasites, and Bacteria in Fecal Samples of Horses with Colic.Pathogens (Basel, Switzerland) · 2023Article
- Prevalence of serum and salivary virus-neutralizing antibodies against equine coronavirus in four riding stables in Japan.Journal of equine science · 2023Article
- Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses.Nature communications · 2022Article
- Bacterial and viral enterocolitis in horses: a review.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Review
- Ensuring Viral Safety of Equine Immunoglobulins during Production.Pharmaceutical chemistry journal · 2022Article
- Article
- Clinical and molecular aspects of veterinary coronaviruses.Virus research · 2021Review
- Seroprevalence and Risk Factors for Exposure to Equine Coronavirus in Apparently Healthy Horses in Israel.Animals : an open access journal from MDPI · 2021Article
- Coronaviruses in farm animals: Epidemiology and public health implications.Veterinary medicine and science · 2021Review
- Pathology of Coronavirus Infections: A Review of Lesions in Animals in the One-Health Perspective.Animals : an open access journal from MDPI · 2020Review
- Equine Coronavirus-Associated Colitis in Horses: A Retrospective Study.Journal of equine veterinary science · 2020Article
- Novel findings from a beta coronavirus outbreak on an American Miniature Horse breeding farm in upstate New York.Equine veterinary education · 2020Article
- Development and Validation of a S1 Protein-Based ELISA for the Specific Detection of Antibodies against Equine Coronavirus.Viruses · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new equine coronavirus was isolated from the feces of adult horses with pyrogenic and enteric disease. The disease outbreak was mainly observed among 2- to 4-year-old horses living in stables of a draft-horse racetrack in Japan. On comparing the isolated virus (isolate Tokachi09) with the equine coronavirus NC99 strain, no significant differences were observed in several biological properties such as hemagglutinating activity, antigenicity (in indirect immunofluorescence and neutralization tests), and one-step growth (in cell culture). The sequences of the nucleocapsid and spike genes of isolate Tokachi09 showed identical size (1341 and 4092 nucleotides, 446 and 1363 amino acids, respectively) and high similarity (98.0% and 99.0% at the nucleotides, 97.3% and 99.0% at the amino acids, respectively) to those of strain NC99. However, the isolate had a 185-nucleotide deletion from four bases after the 3'-terminal end of the spike gene, resulting in the absence of the open reading frame predicted to encode a 4.7-kDa nonstructural protein in strain NC99. These results suggest that the 4.7-kDa nonstructural protein is not essential for viral replication, at least in cell culture, and that the Japanese strain probably originated from a different lineage to the North American strain. This is the first equine coronavirus to be isolated from adult horses with pyrogenic and enteric disease.
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Registered trials
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