Evidence map›Paper›PMID 21272867›Full record

ReviewFertility and sterility2011

Breast cancer and fertility preservation.

S Samuel Kim, Jennifer Klemp, Carol Fabian

Abstract readEvaluation StudyReview
In one paragraph

Review in Fertility and sterility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Fertility preservation in young women with breast cancer.Journal of assisted reproduction and genetics · 2012
    Guideline
  2. Guideline
  3. Oocyte vitrification for oncological and social reasons.Turkish journal of obstetrics and gynecology · 2023
    Article
  4. Article
  5. Irinotecan (CPT-11) Treatment Induces Mild Gonadotoxicity.Frontiers in reproductive health · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Women's experiences with information provision and deciding about fertility preservation in the Netherlands: 'satisfaction in general, but unmet needs'.Health expectations : an international journal of public participation in health care and health policy · 2015
    Article
  14. Article
  15. Review
  16. Article
  17. Fertility preservation in breast cancer patients.Breast cancer (Tokyo, Japan) · 2014
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

S Samuel KimDivision of Reproductive Endocrinology and Infertility, University of Kansas School of Medicine, Kansas City, Kansas, USA. skim2@kumc.edu
Jennifer Klemp
Carol Fabian
University of Kansas Medical Center · USUniversity of Kansas · US

Funding

Kansas BIRCWH Career Development Program Women's HealthK12HD052027 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CARLSON, SUSAN E · 2005 to 2014
$5.0M
NICHD NIH HHS K12 HD052027
6 · The paper itself

Abstract

objectiveTo review the benefits of adjuvant systemic therapy given to women with breast cancer of reproductive age, its effects on fertility, and options for fertility preservation.

designPublications relevant to fertility preservation and breast cancer were identified through a PubMed database search. CONCLUSION(S): Most women who develop invasive breast cancer under age 40 will be advised to undergo adjuvant chemotherapy with or without extended antihormonal therapy to reduce the risk of recurrence and death from breast cancer. Adjuvant chemotherapy particularly with alkylating agents such as cyclophosphamide is gonadotoxic and markedly accelerates the rate of age-related ovarian follicle loss. Although loss of fertility is an important issue for young cancer survivors, there is often little discussion about fertility preservation before initiation of adjuvant therapy. Greater familiarity with prognosis and effects of different types of adjuvant therapy on the part of infertility specialists and fertility preservation options such cryopreservation of embryos, oocytes, and ovarian tissue on the part of oncologists would facilitate these discussions. Establishment of rapid fertility consultation links within cancer survivorship programs can help ensure that every young woman who is likely to undergo gonadotoxic cancer treatment is counseled about the effects of therapy and options available to her to increase the likelihood of childbearing after cancer treatment.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCarcinomaChemotherapy, AdjuvantCryopreservationEmbryo, MammalianFemaleFertilityHumansInfertility, FemaleOocytesPregnancyRadiotherapy, AdjuvantRecurrenceTissue Preservation

Identifiers

PMID21272867
PMCPMC3939612
OpenAlexW2125959581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.