ArticleArchives of physical medicine and rehabilitation2011
Enhancing muscle force and femur compressive loads via feedback-controlled stimulation of paralyzed quadriceps in humans.
Article in Archives of physical medicine and rehabilitation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Strategies for Rapid Muscle Fatigue Reduction during FES Exercise in Individuals with Spinal Cord Injury: A Systematic Review.PloS one · 2016Pooled it
- Active-resisted stance modulates regional bone mineral density in humans with spinal cord injury.The journal of spinal cord medicine · 2013Trial
- A minimal dose of electrically induced muscle activity regulates distinct gene signaling pathways in humans with spinal cord injury.PloS one · 2014Article
- Fatigue modulates synchronous but not asynchronous soleus activation during stimulation of paralyzed muscle.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2013Article
- Spinal Cord Injury and Osteoporosis: Causes, Mechanisms, and Rehabilitation Strategies.International journal of physical medicine & rehabilitation · 2013Article
- High dose compressive loads attenuate bone mineral loss in humans with spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- A biomechanical analysis of exercise in standing, supine, and seated positions: Implications for individuals with spinal cord injury.The journal of spinal cord medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo compare paralyzed quadriceps force properties and femur compressive loads in an upright functional task during conventional constant-frequency stimulation and force feedback-modulated stimulation.
designCrossover trial.
settingResearch laboratory.
participantsSubjects (N=13; 12 men, 1 woman) with motor-complete spinal cord injury.
interventionsSubjects performed 2 bouts of 60 isometric quadriceps contractions while supported in a standing frame. On separate days, subjects received constant-frequency stimulation at 20Hz (CONST) or frequency-modulated stimulation triggered by a change in force (FDBCK). During FDBCK, a computer algorithm responded to each 10% reduction in force with a 20% increase in stimulation frequency.
main outcome measuresA biomechanical model was used to derive compressive loads on the femur, with a target starting dose of load equal to 1.5 times body weight.
resultsPeak quadriceps force and fatigue index were higher for FDBCK than CONST (P<.05). Within-train force decline was greater during FDBCK bouts, but mean force remained above CONST values (P<.05). As fatigue developed during repetitive stimulation, FDBCK was superior to CONST for maintenance of femur compressive loads (P<.05).
conclusionsFeedback-modulated stimulation in electrically activated stance is a viable method to maximize the physiologic performance of paralyzed quadriceps muscle. Compared with CONST, FDBCK yielded compressive loads that were closer to a targeted dose of stress with known osteogenic potential. Optimization of muscle force with FDBCK may be a useful tactic for future training-based antiosteoporosis protocols.
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