ArticleInternational journal of pharmaceutics2011
Optimization of microdermabrasion for controlled removal of stratum corneum.
Article in International journal of pharmaceutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Advancements in Skin-Mediated Drug Delivery: Mechanisms, Techniques, and Applications.Advanced healthcare materials · 2024Review
- A Comprehensive Review of Non-Energy-Based Treatments for Atrophic Acne Scarring.Clinical, cosmetic and investigational dermatology · 2022Review
- Review
- Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies.Current drug delivery · 2019Review
- Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes.International journal of nanomedicine · 2015Article
- Strengthening the skin with topical delivery of keratinocyte growth factor-1 using a novel DNA plasmid.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Cutaneous immunization: an evolving paradigm in influenza vaccines.Expert opinion on drug delivery · 2014Review
- Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum.Pharmaceutical research · 2013Article
- Insulin therapies: Current and future trends at dawn.World journal of diabetes · 2013Article
- Recovery of skin barrier after stratum corneum removal by microdermabrasion.AAPS PharmSciTech · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Microdermabrasion has been shown to increase skin permeability for transdermal drug delivery by damaging or removing skin's outer layer, stratum corneum. However, relationships between microdermabrasion parameters and effects on the stratum corneum barrier have not been developed. In this study, we determined the effect of microdermabrasion crystal flow rate, time, and suction pressure applied in both static and dynamic modes on the extent of stratum corneum removal from excised porcine skin. In addition to controlling the depth of tissue removal by microdermabrasion parameters, we also controlled the area of tissue removal by applying a metal mask patterned with 125- or 250-μm holes to selectively expose small spots of tissue to microdermabrasion. We found that the extent of stratum corneum removal depended strongly on the crystal flow rate and exposure time and only weakly on pressure or static/dynamic mode operation. Masking the skin was effective to localize stratum corneum removal to exposed sites. Overall, this study demonstrates that optimized microdermabrasion in combination with a mask can be used to selectively remove stratum corneum with three-dimensional control, which is important to translating this technique into a novel method of transdermal drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.