Evidence map›Paper›PMID 21272578›Full record

ArticleExperimental neurology2011

Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection.

Matthias D Ziegler, Derek Hsu, Aya Takeoka, Hui Zhong, Almudena Ramón-Cueto, Patricia E Phelps, Roland R Roy, V Reggie Edgerton

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  9. Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022
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  13. Stem cell/cellular interventions in human spinal cord injury: Is it time to move from guidelines to regulations and legislations? Literature review and Spinal Cord Society position statement.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Matthias D ZieglerDepartment of Integrative Biology and Physiology, University of California-Los Angeles, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA.
Derek Hsu
Aya Takeoka
Hui Zhong
Almudena Ramón-Cueto
Patricia E Phelps
Roland R Roy
V Reggie Edgerton
University of California, Los Angeles · USInstituto de Biomedicina de Valencia · ES

Funding

Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCIR01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2008 to 2013
$4.9M
Combined OEG transplantation and step training promote regeneration in adult SCIR01NS054159 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2006 to 2009
$2.4M
NIBIB NIH HHS R01 EB007615NINDS NIH HHS NS054159NINDS NIH HHS R01 NS054159
6 · The paper itself

Abstract

Spinal Wistar Hannover rats injected with olfactory ensheathing glia (OEG) have been shown to recover some bipedal stepping and climbing abilities. Given the intrinsic ability of the spinal cord to regain stepping with pharmacological agents or epidural stimulation after a complete mid-thoracic transection, we asked if functional recovery after OEG injections is due to changes in the caudal stump or facilitation of functional regeneration of axons across the transection site. OEG were injected rostral and caudal to the transection site immediately after transection. Robotically assisted step training in the presence of intrathecal injections of a 5-HT(2A) receptor agonist (quipazine) was used to facilitate recovery of stepping. Bipedal stepping as well as climbing abilities were tested over a 6-month period post-transection to determine any improvement in hindlimb functional due to OEG injections and/or step training. The ability for OEG to facilitate regeneration was analyzed electrophysiologically by transcranially stimulating the brainstem and recording motor evoked potentials (MEP) with chronically implanted intramuscular EMG electrodes in the soleus and tibalis anterior with and without intrathecal injections of noradrenergic, serotonergic, and glycinergic receptor antagonists. Analyses confirmed that along with improved stepping ability and increased use of the hindlimbs during climbing, only OEG rats showed recovery of MEP. In addition the MEP signals were eliminated after a re-transection of the spinal cord rostral to the original transection and were modified in the presence of receptor antagonists. These data indicate that improved hindlimb function after a complete transection was coupled with OEG-facilitated functional regeneration of axons. This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair.

Indexed as

Thoracic VertebraeAnimalsAxonsCell TransplantationExercise TherapyNerve RegenerationNeurogliaOlfactory BulbRatsRats, WistarRecovery of FunctionSpinal Cord Injuries

Identifiers

PMID21272578
PMCPMC3085566
OpenAlexW2087237431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.