ArticleBMC genomics2011
Eukaryote-wide sequence analysis of mitochondrial β-barrel outer membrane proteins.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The dynamic lateral gate of the mitochondrial β-barrel biogenesis machinery is blocked by darobactin A.Nature communications · 2025Article
- Review
- Article
- Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria.PLoS genetics · 2023Article
- Mitochondrial protein translocation machinery: From TOM structural biogenesis to functional regulation.The Journal of biological chemistry · 2022Review
- High quality genome assembly of the amitochondriate eukaryoteMicrobial genomics · 2021Article
- Building Better Barrels - β-barrel Biogenesis and Insertion in Bacteria and Mitochondria.Journal of molecular biology · 2021Review
- The assembly of β-barrel membrane proteins by BAM and SAM.Molecular microbiology · 2021Review
- Targeting and Insertion of Membrane Proteins in Mitochondria.Frontiers in cell and developmental biology · 2021Review
- A C-Terminally Truncated Variant ofFrontiers in physiology · 2021Article
- Structural insight into mitochondrial β-barrel outer membrane protein biogenesis.Nature communications · 2020Article
- Transport of Proteins into Mitochondria.The protein journal · 2019Review
- Thylakoid membranes contain a non-selective channel permeable to small organic molecules.The Journal of biological chemistry · 2018Article
- All-atom 3D structure prediction of transmembrane β-barrel proteins from sequences.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- MitoFates: improved prediction of mitochondrial targeting sequences and their cleavage sites.Molecular & cellular proteomics : MCP · 2015Article
- A novel Mitosomal β-barrel Outer Membrane Protein in Entamoeba.Scientific reports · 2015Article
- The phosphatidic acid binding site of the Arabidopsis trigalactosyldiacylglycerol 4 (TGD4) protein required for lipid import into chloroplasts.The Journal of biological chemistry · 2013Article
- TMBB-DB: a transmembrane β-barrel proteome database.Bioinformatics (Oxford, England) · 2012Article
- Identification of two voltage-dependent anion channel-like protein sequences conserved in Kinetoplastida.Biology letters · 2012Article
- VDAC proteomics: post-translation modifications.Biochimica et biophysica acta · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe outer membranes of mitochondria are thought to be homologous to the outer membranes of Gram negative bacteria, which contain 100's of distinct families of β-barrel membrane proteins (BOMPs) often forming channels for transport of nutrients or drugs. However, only four families of mitochondrial BOMPs (MBOMPs) have been confirmed to date. Although estimates as high as 100 have been made in the past, the number of yet undiscovered MBOMPs is an open question. Fortunately, the recent discovery of a membrane integration signal (the β-signal) for MBOMPs gave us an opportunity to look for undiscovered MBOMPs.
resultsWe present the results of a comprehensive survey of eukaryotic protein sequences intended to identify new MBOMPs. Our search employs recent results on β-signals as well as structural information and a novel BOMP predictor trained on both bacterial and mitochondrial BOMPs. Our principal finding is circumstantial evidence suggesting that few MBOMPs remain to be discovered, if one assumes that, like known MBOMPs, novel MBOMPs will be monomeric and β-signal dependent. In addition to this, our analysis of MBOMP homologs reveals some exceptions to the current model of the β-signal, but confirms its consistent presence in the C-terminal region of MBOMP proteins. We also report a β-signal independent search for MBOMPs against the yeast and Arabidopsis proteomes. We find no good candidates MBOMPs in yeast but the Arabidopsis results are less conclusive.
conclusionsOur results suggest there are no remaining MBOMPs left to discover in yeast; and if one assumes all MBOMPs are β-signal dependent, few MBOMP families remain undiscovered in any sequenced organism.
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