ArticleCell division2011
The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.
Article in Cell division, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Mitotic kinases are emerging therapeutic targets against metastatic breast cancer.Cell division · 2024Review
- Epigenetic alterations impede epithelial-mesenchymal transition by modulating centrosome amplification and Myc/RAS axis in triple negative breast cancer cells.Scientific reports · 2023Article
- The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells.Scientific reports · 2021Article
- Cytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia.Journal of cellular and molecular medicine · 2018Article
- Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers.Molecular cancer therapeutics · 2018Review
- Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity.Journal of cancer metastasis and treatment · 2018Article
- The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1.Oncotarget · 2017Article
- NEK7 is required for G1 progression and procentriole formation.Molecular biology of the cell · 2017Article
- Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes.Scientific reports · 2016Article
- Centrosome - a promising anti-cancer target.Biologics : targets & therapy · 2016Review
- Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis.Oncotarget · 2015Article
- Turning the headlights on novel cancer biomarkers: Inspection of mechanics underlying intratumor heterogeneity.Molecular aspects of medicine · 2015Review
- Article
- CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.Cancer research · 2015Article
- E2F activators signal and maintain centrosome amplification in breast cancer cells.Molecular and cellular biology · 2014Article
- Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells.Cell division · 2014Article
- The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2013Article
- Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis.Cell division · 2013Article
- Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.PloS one · 2013Article
- CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer.Neoplasia (New York, N.Y.) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered tumor suppressors lead to centrosome amplification and aneuploidy suggests that oncogenes and altered tumor suppressors are a major source of genomic instability in tumors, and that they generate those abnormal processes to initiate and sustain tumorigenesis. We discuss how altered tumor suppressors and oncogenes utilize the cell cycle regulatory machinery to signal centrosome amplification and aneuploidy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.