Evidence map›Paper›PMID 21272222›Full record

ArticleCongestive heart failure (Greenwich, Conn.)

Blood volume measurements in patients with heart failure and a preserved ejection fraction: implications for diagnosing anemia.

Bassel Noumi, Sergio Teruya, Say Salomon, Stephen Helmke, Mathew S Maurer

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Congestive heart failure (Greenwich, Conn.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
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  5. Article
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  8. Review
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  11. Update on heart failure with preserved ejection fraction.Current cardiovascular risk reports · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bassel NoumiClinical Cardiovascular Research Laboratory for the Elderly, Columbia University Medical Center, Allen Hospital of New York Presbyterian, 5141 Broadway, New York, NY 10034, USA.
Sergio Teruya
Say Salomon
Stephen Helmke
Mathew S Maurer
Columbia University Irving Medical Center · US

Funding

Pathophysiology of Heart Failure with a Normal Ejection Fraction in the ElderlyR01AG027518 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S · 2007 to 2010
$2.1M
Midcareer Mentoring Award for Patient Oriented Research in Geriatric CardiologyK24AG036778 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S · 2010 to 2020
$1.6M
NIA NIH HHS K24 AG036778NIA NIH HHS K24-AG036778-01A1NIA NIH HHS R01 AG027518NIA NIH HHS R01 AG027518-01A1
6 · The paper itself

Abstract

Racial differences in the prevalence of anemia in patients with heart failure have been noted. The diagnosis of anemia in heart failure patients can be confounded by many factors. Plasma volume expansion is one of the most prominent confounders. The authors investigated the difference of anemia prevalence using two different diagnostic techniques: peripheral hemoglobin recommended by the World Health Organization criteria and blood volume (BV) analysis. Racial disparities in the prevalence of anemia using both measures were compared. Sixty patients with heart failure and preserved ejection fraction (HFPEF) underwent measurement of BV by a radio-labeled albumin technique. Anemia was defined by both WHO criteria and by measured red blood cell volume (RBCV) >10% below ideal. Anemia was found in 67% of patients by the peripheral hemoglobin technique with no racial disparity. Only 35% of the patients had anemia by the BV analysis, with a 2-fold higher prevalence among Hispanics compared with whites and blacks. In patients with HFPEF, the diagnosis of anemia based on hemoglobin is confounded by plasma volume derangements resulting in significant overdiagnosis in this cohort. Racial differences in the rate of anemia were found. Such data could have important implications for the diagnosis and management of anemia in ethnic minorities with HFPEF.

Indexed as

Blood VolumeHemodynamicsPlasma SubstitutesVentricular Function, LeftAgedAnemiaCross-Sectional StudiesFemaleHealth Status DisparitiesHeart FailureHumansMalePrevalenceRacial GroupsRisk FactorsStatistics, NonparametricPlasma Substitutes

Identifiers

PMID21272222
PMCPMC3777395
OpenAlexW2128384627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.