Evidence map›Paper›PMID 21271986›Full record

ReviewClinical science (London, England : 1979)2011

Healthy aging and disease: role for telomere biology?

Haidong Zhu, Matthew Belcher, Pim van der Harst

Abstract readReview
In one paragraph

Review in Clinical science (London, England : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Telomere Biology and Thoracic Aortic Aneurysm.International journal of molecular sciences · 2017
    Pooled it
  2. Pooled it
  3. Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
  4. Trial
  5. Trial
  6. Frontiers in endocrinology · 2026
    Article
  7. Article
  8. Telomere Length, HLA, and Longevity-Results from a Multicenter Study.International journal of molecular sciences · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. The Aging Heart: A Molecular and Clinical Challenge.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Haidong ZhuDepartment of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA. hzhu@mail.mcg.edu
Matthew Belcher
Pim van der Harst

Funding

Inflammatory factors, genes and stress induced pressure natriuresis in youthR21HL085817 · NHLBI · AUGUSTA UNIVERSITY · PI ZHU, HAIDONG · 2006 to 2007
$289k
NHLBI NIH HHS HL85817
6 · The paper itself

Abstract

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.

Indexed as

AgingCardiovascular DiseasesChronic DiseaseDiabetes MellitusHumansStem CellsTelomeraseTelomereTelomerase

Identifiers

PMID21271986
PMCPMC3035527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.