ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2011
Intra-and inter-reader reliability of semi-automated quantitative morphometry measurements and vertebral fracture assessment using lateral scout views from computed tomography.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 43 citations in OpenAlex.
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- Opportunistic diagnosis of osteoporosis, fragile bone strength and vertebral fractures from routine CT scans; a review of approved technology systems and pathways to implementation.Therapeutic advances in musculoskeletal disease · 2021Review
- Bone morbidity in pediatric acute lymphoblastic leukemia.Annals of pediatric endocrinology & metabolism · 2020Article
- Diagnosis of osteoporotic vertebral fractures in children.Pediatric radiology · 2019Review
- The protocol for the Prospective Urban Rural Epidemiology China Action on Spine and Hip status study.Quantitative imaging in medicine and surgery · 2018Article
- Diagnosis of vertebral deformities on chest CT and DXA compared to routine lateral thoracic spine X-ray.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- What is changed in the diagnosis of osteoporosis: the role of radiologists.Quantitative imaging in medicine and surgery · 2018Article
- Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia.Quantitative imaging in medicine and surgery · 2018Review
- Thoracic Kyphosis and Physical Function: The Framingham Study.Journal of the American Geriatrics Society · 2017Article
- Incorporation of CT-based measurements of trunk anatomy into subject-specific musculoskeletal models of the spine influences vertebral loading predictions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Evaluation of a new approach to compute intervertebral disc height measurements from lateral radiographic views of the spine.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Heritability of Thoracic Spine Curvature and Genetic Correlations With Other Spine Traits: The Framingham Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- Diagnosis of vertebral fractures in children: is a simplified algorithm-based qualitative technique reliable?Pediatric radiology · 2016Article
- Type 2 diabetes mellitus and bone fragility: Special focus on bone imaging.Osteoporosis and sarcopenia · 2016Review
- Reliability and accuracy of scout CT in the detection of vertebral fractures.The British journal of radiology · 2013Article
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6 authors at 3 institutions in 1 country.
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Abstract
unlabelledIntra-and inter-reader reliability of semi-automated quantitative vertebral morphometry measurements was determined using lateral computed tomography (CT) scout views. The method requires less time than conventional morphometry. Reliability was excellent for vertebral height measurements, good for height ratios, and comparable to semi-quantitative grading by radiologists for identification of vertebral fractures.
introductionUnderdiagnosis and undertreatment of vertebral fracture (VFx) is a well-known problem worldwide. Thus, new methods are needed to facilitate identification of VFx. This study aimed to determine intra- and inter-reader reliability of semi-automated quantitative vertebral morphometry based on shape-based statistical modeling (SpineAnalyzer, Optasia Medical, Cheadle, UK).
methodsTwo non-radiologists independently assessed vertebral morphometry from CT lateral scout views at two time points in 96 subjects (50 men, 46 women, 70.3 ± 8.9 years) selected from the Framingham Heart Study Offspring and Third Generation Multi-Detector CT Study. VFxs were classified based solely on morphometry measurements using Genant's criteria. Intraclass correlation coefficients (ICCs), root mean squared coefficient of variation (RMS CV) and kappa (k) statistics were used to assess reliability.
resultsWe analyzed 1,246 vertebrae in 96 subjects. The analysis time averaged 5.4 ± 1.7 min per subject (range, 3.2-9.1 min). Intra-and inter-reader ICCs for vertebral heights were excellent (>0.95) for all vertebral levels combined. Intra-and inter-reader RMS CV for height measurements ranged from 2.5% to 3.9% and 3.3% to 4.4%, respectively. Reliability of vertebral height ratios was good to fair. Based on morphometry measurements alone, readers A and B identified 51-52 and 46-59 subjects with at least one prevalent VFx, respectively, and there was a good intra-and inter-reader agreement (k = 0.59-0.69) for VFx identification.
conclusionsSemi-automated quantitative vertebral morphometry measurements from CT lateral scout views are convenient and reproducible, and may facilitate assessment of VFx.
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