ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2011
Ringing the changes: emerging roles for DASH at the kinetochore-microtubule Interface.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Ccp1 modulates epigenetic stability at centromeres and affects heterochromatin distribution inThe Journal of biological chemistry · 2018Article
- Genes Important forGenetics · 2018Article
- Evolutionary Turnover of Kinetochore Proteins: A Ship of Theseus?Trends in cell biology · 2016Review
- Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.Cold Spring Harbor perspectives in biology · 2015Review
- Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.Molecular & cellular proteomics : MCP · 2013Article
- Regulatory mechanisms of kinetochore-microtubule interaction in mitosis.Cellular and molecular life sciences : CMLS · 2013Review
- Csi1 links centromeres to the nuclear envelope for centromere clustering.The Journal of cell biology · 2012Article
- Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.Journal of cell science · 2012Article
- Csi1 illuminates the mechanism and function of Rabl configuration.Nucleus (Austin, Tex.)Article
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Authors and funding
2 authors.
Funding
Abstract
Regulated interaction between kinetochores and the mitotic spindle is essential for the fidelity of chromosome segregation. Potentially deleterious attachments are corrected during prometaphase and metaphase. Correct attachments must persist during anaphase, when spindle-generated forces separate chromosomes to opposite poles. In yeast, the heterodecameric DASH complex plays a vital pole in maintaining this link. In vitro DASH forms both oligomeric patches and rings that can form load-bearing attachments with the tips of polymerising and depolymerising microtubules. In vivo, DASH localises primarily at the kinetochore, and has a role maintaining correct attachment between spindles and chromosomes in both Saccharomyces cerevisiae and Schizosaccharomyces pombe. Recent work has begun to describe how DASH acts alongside other components of the outer kinetochore to create a dynamic, regulated kinetochore-microtubule interface. Here, we review some of the key experiments into DASH function and discuss their implications for the nature of kinetochore-microtubule attachments in yeast and other organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.