ReviewJournal of bioenergetics and biomembranes2011
Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets.
Review in Journal of bioenergetics and biomembranes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Antifungal Properties ofPlants (Basel, Switzerland) · 2024Article
- A Novel Mitochondrial Targeted Compound Phosundoxin Showing Potent Antifungal Activity against Common Clinical Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2023Article
- Exposure of Candida parapsilosis to the silver(I) compound SBC3 induces alterations in the proteome and reduced virulence.Metallomics : integrated biometal science · 2022Article
- Marine Macroalgae, a Source of Natural Inhibitors of Fungal Phytopathogens.Journal of fungi (Basel, Switzerland) · 2021Review
- Deletion of the PA4427-PA4431 Operon ofMicroorganisms · 2021Article
- Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives againstAntibiotics (Basel, Switzerland) · 2021Article
- Mitochondrial Inheritance in Phytopathogenic Fungi-Everything Is Known, or Is It?International journal of molecular sciences · 2020Review
- Fungal Seed Pathogens of Wild Chili Peppers Possess Multiple Mechanisms To Tolerate Capsaicinoids.Applied and environmental microbiology · 2020Article
- Chemical Compositions of Propolis from China and the United States and their Antimicrobial Activities AgainstMolecules (Basel, Switzerland) · 2019Article
- Article
- Heterologous expression of mitochondrial nicotinamide adenine dinucleotide transporter (Ndt1) from Aspergillus fumigatus rescues impaired growth in Δndt1Δndt2 Saccharomyces cerevisiae strain.Journal of bioenergetics and biomembranes · 2017Article
- Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival.Eukaryotic cell · 2014Article
- Humic substances enhance growth and respiration in the basidiomycetes Trametes maxima under carbon limited conditions.Journal of chemical ecology · 2014Article
- Mitochondrial dysfunction is involved in the toxic activity of boric acid against Saprolegnia.PloS one · 2014Article
- Computational approaches for discovery of common immunomodulators in fungal infections: towards broad-spectrum immunotherapeutic interventions.BMC microbiology · 2013Article
- Targeting the mitochondrial respiratory chain of Cryptococcus through antifungal chemosensitization: a model for control of non-fermentative pathogens.Molecules (Basel, Switzerland) · 2013Article
- Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Article
- Mitochondrial respiratory pathways inhibition in Rhizopus oryzae potentiates activity of posaconazole and itraconazole via apoptosis.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequency of opportunistic fungal infection has increased drastically, mainly in patients who are immunocompromised due to organ transplant, leukemia or HIV infection. In spite of this, only a few classes of drugs with a limited array of targets, are available for antifungal therapy. Therefore, more specific and less toxic drugs with new molecular targets is desirable for the treatment of fungal infections. In this context, searching for differences between mitochondrial mammalian hosts and fungi in the classical and alternative components of the mitochondrial respiratory chain may provide new potential therapeutic targets for this purpose.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.