Evidence map›Paper›PMID 21271250›Full record

ReviewSeminars in immunopathology2011

Lung transplantation: infection, inflammation, and the microbiome.

Takeshi Nakajima, Vyachesav Palchevsky, David L Perkins, John A Belperio, Patricia W Finn

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 54 citations in OpenAlex.

  1. Outpatient parenteral antibiotic therapy in non-cystic fibrosis lung transplant recipients: characteristics, efficacy and safety.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  2. Article
  3. Article
  4. Pseudomonas-dominant microbiome elicits sustained IL-1β upregulation in alveolar macrophages from lung transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023
    Article
  5. Article
  6. Pediatric lung transplantation: Dynamics of the microbiome and bronchiolitis obliterans in cystic fibrosis.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2020
    Observational
  7. [Predictors for the Bronchiolitis Obliterans Syndrome in Lung Transplant Patient].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020
    Review
  8. Review
  9. Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017
    Article
  10. The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
  11. Review
  12. Review
  13. Review
  14. Small airways diseases, excluding asthma and COPD: an overview.European respiratory review : an official journal of the European Respiratory Society · 2013
    Article
  15. Article
  16. Article
  17. Update on lung transplantation: programmes, patients and prospects.European respiratory review : an official journal of the European Respiratory Society · 2012
    Review
  18. The microbiome of the lung.Translational research : the journal of laboratory and clinical medicine · 2012
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Takeshi NakajimaDivision of Pulmonary and Critical Medicine, Department of Medicine, University of California, La Jolla, CA 92093, USA.
Vyachesav Palchevsky
David L Perkins
John A Belperio
Patricia W Finn
University of California, Los Angeles · USUniversity of California, San Diego · US

Funding

Innate Immunity In Allergic and Non-Allergic ResponsesR01HL077900 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FINN, PATRICIA W · 2005 to 2008
$1.5M
Transplantation: Alloimmune NetworksR01AI075317 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FINN, PATRICIA W, PERKINS, DAVID LINN · 2009 to 2011
$803k
NHLBI NIH HHS R01 HL077900NHLBI NIH HHS R01-HL077900NIAID NIH HHS R01 AI075317NIAID NIH HHS R01-AI075317
6 · The paper itself

Abstract

Lung transplantation is the only therapeutic option for patients with end-stage pulmonary disorders. Despite the improvements in surgical techniques and immunosuppressive therapy, allograft function and long-term survival are limited by the development of chronic lung transplant rejection. In this review, we focus on bronchiolitis obliterans syndrome (BOS) which is the major manifestation of chronic lung allograft rejection. We specifically review the effect of infection, a risk factor for BOS, cytokines/chemokines in the pathogenesis of BOS, and the potential link between the allograft microbiome and immune responses that may mediate the development of BOS. Understanding the allograft microbiome and how it relates to the pathologic mechanisms of BOS may suggest targeted therapies to improve long-term survival post-lung transplantation.

Indexed as

AnimalsBronchiolitis ObliteransCytokinesDisease SusceptibilityHumansInfectionsInflammationLungLung TransplantationMetagenomeSyndromeT-Lymphocytes, RegulatoryTransplantation, HomologousCytokines

Identifiers

PMID21271250
OpenAlexW1984186009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.