Evidence map›Paper›PMID 21270831›Full record

ArticleGenes and immunity2011

Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population.

M V Prasad Linga Reddy, H Wang, S Liu, B Bode, J C Reed, R D Steed, S W Anderson, L Steed, D Hopkins, J-X She

Abstract read
In one paragraph

Article in Genes and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. The Association betweenBioMed research international · 2019
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  12. Autoimmunity in Primary Immunodeficiencies (PID).Clinical reviews in allergy & immunology · 2023
    Review
  13. International journal of molecular sciences · 2023
    Review
  14. Renalase: a novel regulator of cardiometabolic and renal diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Cavβ3 Regulates CaDiabetes · 2021
    Article
  19. β-Cell autophagy in the pathogenesis of type 1 diabetes.American journal of physiology. Endocrinology and metabolism · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M V Prasad Linga ReddyCenter for Biotechnology and Genomic Medicine, and Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA.
H Wang
S Liu
B Bode
J C Reed
R D Steed
S W Anderson
L Steed
D Hopkins
J-X She

Funding

The TEDDY Study: Georgia/Florida Clinical CenterUC4DK063865 · NIDDK · AUGUSTA UNIVERSITY · PI SHE, JIN-XIONG · 2013 to 2013
$5.3M
Studies of the Immunopathogenesis of Type 1 DiabetesR01HD037800 · NICHD · UNIVERSITY OF FLORIDA · PI SHE, JIN-XIONG · 1999 to 2006
$4.6M
Proteomic changes/progression of human type 1 diabetesR33HD050196 · NICHD · AUGUSTA UNIVERSITY · PI SHE, JIN-XIONG · 2006 to 2008
$1.5M
Development of microarray-based biomarkers for type 1 diR33DK069878 · NIDDK · AUGUSTA UNIVERSITY · PI SHE, JIN-XIONG · 2006 to 2008
$1.1M
NICHD NIH HHS 2R01HD37800NICHD NIH HHS 4R33HD050196NICHD NIH HHS R01 HD037800NICHD NIH HHS R33 HD050196NIDDK NIH HHS 4R33DK069878NIDDK NIH HHS R33 DK069878NIDDK NIH HHS UC4 DK063865
6 · The paper itself

Abstract

The present study was conducted to assess genetic associations for type 1 diabetes (T1D) reported in previous genome-wide association studies (GWAS). A total of 21 previously reported single-nucleotide polymorphisms (SNPs) were genotyped by TaqMan assays in 1434 Caucasian T1D patients and 1864 normal controls from Georgia. Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association.

Indexed as

Genome-Wide Association StudyAdolescentAge of OnsetAllelesChildChromosome MappingDiabetes Mellitus, Type 1FemaleGenetic Predisposition to DiseaseGenotypeGeorgiaHumansMalePolymorphism, Single NucleotideWhite PeopleYoung Adult

Identifiers

PMID21270831
PMCPMC3952552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.