ArticleGenetics in medicine : official journal of the American College of Medical Genetics2011
Patient reactions to personalized medicine vignettes: an experimental design.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- International survey of patients undergoing percutaneous coronary intervention and their attitudes toward pharmacogenetic testing.Pharmacogenetics and genomics · 2019Trial
- Racial minority group interest in direct-to-consumer genetic testing: findings from the PGen study.Journal of community genetics · 2017Article
- Patient Perceptions of Care as Influenced by a Large Institutional Pharmacogenomic Implementation Program.Clinical pharmacology and therapeutics · 2017Article
- Choices for return of primary and secondary genomic research results of 790 members of families with Mendelian disease.European journal of human genetics : EJHG · 2017Article
- Interest in genomic SNP testing for prostate cancer risk: a pilot survey.Hereditary cancer in clinical practice · 2015Article
- Attitudes of non-African American focus group participants toward return of results from exome and whole genome sequencing.American journal of medical genetics. Part A · 2014Article
- Self-guided management of exome and whole-genome sequencing results: changing the results return model.Genetics in medicine : official journal of the American College of Medical Genetics · 2013Article
- Attitudes of African Americans toward return of results from exome and whole genome sequencing.American journal of medical genetics. Part A · 2013Article
- Concept-based learning of personalized prescribing.British journal of clinical pharmacology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeTranslational investigation on personalized medicine is in its infancy. Exploratory studies reveal attitudinal barriers to "race-based medicine" and cautious optimism regarding genetically personalized medicine. This study describes patient responses to hypothetical conventional, race-based, or genetically personalized medicine prescriptions.
methodsThree hundred eighty-seven participants (mean age = 47 years; 46% white) recruited from a Baltimore outpatient center were randomized to this vignette-based experimental study. They were asked to imagine a doctor diagnosing a condition and prescribing them one of three medications. The outcomes are emotional response to vignette, belief in vignette medication efficacy, experience of respect, trust in the vignette physician, and adherence intention.
resultsRace-based medicine vignettes were appraised more negatively than conventional vignettes across the board (Cohen's d = -0.51-0.57-0.64, P < 0.001). Participants rated genetically personalized comparably with conventional medicine (-0.14-0.15-0.17, P = 0.47), with the exception of reduced adherence intention to genetically personalized medicine (Cohen's d = -0.38-0.41-0.44, P = 0.009). This relative reluctance to take genetically personalized medicine was pronounced for racial minorities (Cohen's d = -0.38-0.31-0.25, P = 0.02) and was related to trust in the vignette physician (change in R = 0.23, P < 0.001).
conclusionsThis study demonstrates a relative reluctance to embrace personalized medicine technology, especially among racial minorities, and highlights enhancement of adherence through improved doctor- patient relationships.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.