ArticleJournal of immunology (Baltimore, Md. : 1950)2011
5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Pooled it
- Lipoxins as Modulators of Diseases.Cells · 2025Review
- Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025Review
- 12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis.Frontiers in immunology · 2023Article
- Immunomodulation of periodontitis with SPMs.Frontiers in oral health · 2023Review
- Immune Response toCurrent issues in molecular biology · 2021Article
- AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis.Frontiers in immunology · 2019Article
- Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology.Molecular aspects of medicine · 2017Review
- Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis.Biochimie · 2017Article
- The role of the LTBSeminars in immunology · 2017Review
- Macrophage LTBJournal of lipid research · 2017Article
- Immune resolution mechanisms in inflammatory arthritis.Nature reviews. Rheumatology · 2017Review
- Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.JCI insight · 2016Article
- Specialized pro-resolving mediators: endogenous regulators of infection and inflammation.Nature reviews. Immunology · 2016Review
- The role of lipoxygenases in pathophysiology; new insights and future perspectives.Redox biology · 2015Review
- Eicosanoid storm in infection and inflammation.Nature reviews. Immunology · 2015Review
- Macrophage Polarization during Murine Lyme Borreliosis.Infection and immunity · 2015Article
- Infection of Interleukin 17 Receptor A-Deficient C3H Mice with Borrelia burgdorferi Does Not Affect Their Development of Lyme Arthritis and Carditis.Infection and immunity · 2015Article
- The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution.Seminars in immunology · 2015Review
- Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology.Mucosal immunology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The enzyme 5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid into the leukotrienes, which are critical regulators of inflammation and inflammatory diseases, such as asthma and arthritis. Although leukotrienes are present in the synovial fluid of Lyme disease patients, their role in the development of Lyme arthritis has not been determined. In the current study, we used a murine model of Lyme arthritis to investigate the role 5-LO products might have in the development of this inflammatory disease. After infection of Lyme arthritis-susceptible C3H/HeJ mice with Borrelia burgdorferi, mRNA expression of 5-LO and 5-LO-activating protein was induced in the joints, and the 5-LO product leukotriene B(4) was produced. Using C3H 5-LO-deficient mice, we demonstrated that 5-LO activity was not necessary for the induction of Lyme arthritis, but that its deficiency resulted in earlier joint swelling and an inability to resolve arthritis as demonstrated by sustained arthritis pathology through day 60 postinfection. Although production of anti-Borrelia IgG was decreased in 5-LO-deficient mice, bacterial clearance from the joints was unaffected. Phagocytosis of B. burgdorferi and efferocytosis of apoptotic neutrophils was defective in macrophages from 5-LO-deficient mice, and uptake of opsonized spirochetes by neutrophils was reduced. These results demonstrate that products of the 5-LO metabolic pathway are not required for the development of disease in all models of arthritis and that caution should be used when targeting 5-LO as therapy for inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.