ArticleGenetics2011
Transcriptional networks for alcohol sensitivity in Drosophila melanogaster.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Alternative 3' Polyadenylation Responses to Acute Ethanol Exposure Differ Between Drosophila Populations.Research square · 2026Article
- Evolution of Plasticity in Response to Ethanol Between Recently Separated Populations ofEcology and evolution · 2026Article
- Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nature reviews. Genetics · 2024Review
- Harnessing changes in open chromatin determined by ATAC-seq to generate insulin-responsive reporter constructs.BMC genomics · 2022Article
- Despite its sequence identity with canonical H4, Drosophila H4r product is enriched at specific chromatin regions.Scientific reports · 2022Article
- Flying Together:International journal of molecular sciences · 2020Review
- Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.Behavioral and brain functions : BBF · 2019Review
- Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster.Heredity · 2018Article
- Epigenetic Mechanisms of Alcohol Neuroadaptation: Insights fromJournal of experimental neuroscience · 2018Review
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- Genetics and genomics of alcohol responses in Drosophila.Neuropharmacology · 2017Review
- Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster.Behavior genetics · 2017Article
- Genetic architecture of natural variation in visual senescence in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway.Genes, brain, and behavior · 2016Article
- Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila.BMC genomics · 2015Article
- Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2015Review
- From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment.Frontiers in psychiatry · 2015Review
- Identification of differentially expressed genes in female Drosophila antonietae and Drosophila meridionalis in response to host cactus odor.BMC evolutionary biology · 2014Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the genetic architecture of polygenic traits requires investigating how complex networks of interacting molecules mediate the effect of genetic variation on organismal phenotypes. We used a combination of P-element mutagenesis and analysis of natural variation in gene expression to predict transcriptional networks that underlie alcohol sensitivity in Drosophila melanogaster. We identified 139 unique P-element mutations (124 in genes) that affect sensitivity or resistance to alcohol exposure. Further analyses of nine of the lines showed that the P-elements affected expression levels of the tagged genes, and P-element excision resulted in phenotypic reversion. The majority of the mutations were in computationally predicted genes or genes with unexpected effects on alcohol phenotypes. Therefore we sought to understand the biological relationships among 21 of these genes by leveraging genetic correlations among genetically variable transcripts in wild-derived inbred lines to predict coregulated transcriptional networks. A total of 32 "hub" genes were common to two or more networks associated with the focal genes. We used RNAi-mediated inhibition of expression of focal genes and of hub genes connected to them in the network to confirm their effects on alcohol-related phenotypes. We then expanded the computational networks using the hub genes as foci and again validated network predictions. Iteration of this approach allows a stepwise expansion of the network with simultaneous functional validation. Although coregulated transcriptional networks do not provide information about causal relationships among their constituent transcripts, they provide a framework for subsequent functional studies on the genetic basis of alcohol sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.