Evidence map›Paper›PMID 21270371›Full record

ReviewThe Journal of nutrition2011

Systems genetics of mineral metabolism.

James C Fleet, Rebecca Replogle, David E Salt

Abstract readReview
In one paragraph

Review in The Journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The nutritional requirements ofGenes & nutrition · 2019
    Review
  6. Analysis of micromineral contents of school meals.Nutrition research and practice · 2014
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

James C FleetDepartment of Foods and Nutrition, Purdue University, West Lafayette, IN 47906, USA. fleet@purdue.edu
Rebecca Replogle
David E Salt
Purdue University West Lafayette · US

Funding

ROLE OF VDR LEVEL IN VITAMIN D-MEDIATED CA ABSORPTIONR01DK054111 · NIDDK · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI FLEET, JAMES C. · 1997 to 2012
$3.2M
The Genetic Basis of Natural Ionomic VariationR01GM078536 · NIGMS · PURDUE UNIVERSITY · PI GUERINOT, MARY LOU · 2007 to 2014
$2.6M
Diet by Gene Interactions Affecting Calcium and Bone MetabolismR21ES019103 · NIEHS · PURDUE UNIVERSITY · PI FLEET, JAMES C. · 2009 to 2010
$752k
NIDDK NIH HHS DK054111NIDDK NIH HHS R01 DK054111NIEHS NIH HHS ES019103NIEHS NIH HHS R21 ES019103NIGMS NIH HHS GM078536NIGMS NIH HHS R01 GM078536
6 · The paper itself

Abstract

Minerals are essential and toxic elements that have an impact on human health. Although we have learned a tremendous amount about the metabolism, biological roles, and health effects of minerals with the tools of biochemistry, cell biology, and molecular genetics, there are gaps in our knowledge of mineral biology that will benefit from new approaches. Forward genetics, whereby variations in phenotypes are mapped to natural genetic variation in the genome, has been successfully used to increase our understanding of many biologically important traits but has not yet been used extensively for mineral metabolism. In addition, the well-appreciated existence of interactions between minerals justifies a broader, systems approach to the study of mineral metabolism, i.e., ionomics. This short review will explain the value of forward genetics and ionomics as tools for exploring mammalian mineral metabolism.

Indexed as

Genetic PhenomenaAnimalsDietGenetic VariationHumansMineralsNutrigenomicsPlantsResearch DesignSystems BiologyToxicogeneticsMinerals

Identifiers

PMID21270371
PMCPMC3040909
OpenAlexW2113574005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.