ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
2010 Carl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation Section: Central neural pathways for thermoregulatory cold defense.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 110 citations in OpenAlex.
- Article
- Sarcolipin-SERCA uncoupling as a plausible heat source for sustaining fever.Frontiers in physiology · 2026Article
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- Update on Chemoreception: Influence on Cardiorespiratory Regulation and Pathophysiology.Clinics in chest medicine · 2019Review
- Development of endothermy in birds: patterns and mechanisms.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Review
- Shivering thermogenesis in humans: Origin, contribution and metabolic requirement.Temperature (Austin, Tex.) · 2017Review
- Article
- Sciatic nerve stimulation activates the retrotrapezoid nucleus in anesthetized rats.Journal of neurophysiology · 2016Article
- Stimulation of the Pontine Parabrachial Nucleus Promotes Wakefulness via Extra-thalamic Forebrain Circuit Nodes.Current biology : CB · 2016Article
- In vivo correlates of thermoregulatory defense in humans: Temporal course of sub-cortical and cortical responses assessed with fMRI.Human brain mapping · 2016Article
- Neurocardiology: a neurobiologist's perspective.The Journal of physiology · 2016Article
- Histamine receptor signaling in energy homeostasis.Neuropharmacology · 2016Review
- Distribution of catecholaminergic presympathetic-premotor neurons in the rat lower brainstem.Neuroscience · 2016Article
- Central neural control of thermoregulation and brown adipose tissue.Autonomic neuroscience : basic & clinical · 2016Review
- Effects of acute and chronic systemic methamphetamine on respiratory, cardiovascular and metabolic function, and cardiorespiratory reflexes.The Journal of physiology · 2016Article
- The Obese Brain--Effects of Bariatric Surgery on Energy Balance Neurocircuitry.Current atherosclerosis reports · 2015Review
- Humans In Hypoxia: A Conspiracy Of Maladaptation?!Physiology (Bethesda, Md.) · 2015Review
- Molecular determinants of the human α2C-adrenergic receptor temperature-sensitive intracellular traffic.Molecular pharmacology · 2015Article
- A vascular mechanistic approach to understanding Raynaud phenomenon.Nature reviews. Rheumatology · 2015Review
- Renal responses produced by microinjection of the kappa opioid receptor agonist, U50-488H, into sites within the rat lamina terminalis.Pharmacology research & perspectives · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Central neural circuits orchestrate the homeostatic repertoire to maintain body temperature during environmental temperature challenges and to alter body temperature during the inflammatory response. This review summarizes the research leading to a model representing our current understanding of the neural pathways through which cutaneous thermal receptors alter thermoregulatory effectors: the cutaneous circulation for control of heat loss, and brown adipose tissue, skeletal muscle, and the heart for thermogenesis. The activation of these effectors is regulated by parallel but distinct, effector-specific core efferent pathways within the central nervous system (CNS) that share a common peripheral thermal sensory input. The thermal afferent circuit from cutaneous thermal receptors includes neurons in the spinal dorsal horn projecting to lateral parabrachial nucleus neurons that project to the medial aspect of the preoptic area. Within the preoptic area, warm-sensitive, inhibitory output neurons control heat production by reducing the discharge of thermogenesis-promoting neurons in the dorsomedial hypothalamus. The rostral ventromedial medulla, including the raphe pallidus, receives projections form the dorsomedial hypothalamus and contains spinally projecting premotor neurons that provide the excitatory drive to spinal circuits controlling the activity of thermogenic effectors. A distinct population of warm-sensitive preoptic neurons controls heat loss through an inhibitory input to raphe pallidus sympathetic premotor neurons controlling cutaneous vasoconstriction. The model proposed for central thermoregulatory control provides a platform for further understanding of the functional organization of central thermoregulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.