ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 67 citations in OpenAlex.
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- Constitutive mTORC1 activation in skeletal muscle increases inflammation but is not sufficient to impair glucose tolerance.Function (Oxford, England) · 2026Article
- Integrative multi-omics uncovers skeletal muscle enhancer programming of cardiorespiratory fitness.bioRxiv : the preprint server for biology · 2025Article
- The Impact of Exercise Capacity on Complex Neuromuscular Adaptations: A Narrative Review Based on a Rat Model System Selectively Bred for Low and High Response to Training.Comprehensive Physiology · 2025Review
- Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression.Scientific reports · 2023Article
- Low Aerobic Capacity Accelerates Lipid Accumulation and Metabolic Abnormalities Caused by High-Fat Diet-Induced Obesity in Postpartum Mice.Nutrients · 2022Article
- High Cardiorespiratory Fitness Protects against Molecular Impairments of Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced Premature Aging.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Staying fit and the obese aging heart condition.Aging · 2021Article
- Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats.Journal of Alzheimer's disease reports · 2021Article
- Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1.Antioxidants (Basel, Switzerland) · 2020Article
- Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training.Physiological genomics · 2020Article
- Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance.Endocrinology · 2019Article
- Cell Signaling Pathways in Mammary Carcinoma Induced in Rats with Low versus High Inherent Aerobic Capacity.International journal of molecular sciences · 2019Article
- Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity.Scientific reports · 2018Article
- Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model.Molecular metabolism · 2018Article
- Region-specific differences in bioenergetic proteins and protein response to acute high fat diet in brains of low and high capacity runner rats.Neuroscience letters · 2018Article
- Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats.PLoS computational biology · 2018Article
- Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise training.PloS one · 2018Article
- Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity.American journal of physiology. Endocrinology and metabolism · 2017Article
- Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease.Diabetes · 2016Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Chronic metabolic diseases develop from the complex interaction of environmental and genetic factors, although the extent to which each contributes to these disorders is unknown. Here, we test the hypothesis that artificial selection for low intrinsic aerobic running capacity is associated with reduced skeletal muscle metabolism and impaired metabolic health. Rat models for low- (LCR) and high- (HCR) intrinsic running capacity were derived from genetically heterogeneous N:NIH stock for 20 generations. Artificial selection produced a 530% difference in running capacity between LCR/HCR, which was associated with significant functional differences in glucose and lipid handling by skeletal muscle, as assessed by hindlimb perfusion. LCR had reduced rates of skeletal muscle glucose uptake (∼30%; P = 0.04), glucose oxidation (∼50%; P = 0.04), and lipid oxidation (∼40%; P = 0.02). Artificial selection for low aerobic capacity was also linked with reduced molecular signaling, decreased muscle glycogen, and triglyceride storage, and a lower mitochondrial content in skeletal muscle, with the most profound changes to these parameters evident in white rather than red muscle. We show that a low intrinsic aerobic running capacity confers reduced insulin sensitivity in skeletal muscle and is associated with impaired markers of metabolic health compared with high intrinsic running capacity. Furthermore, selection for high running capacity, in the absence of exercise training, endows increased skeletal muscle insulin sensitivity and oxidative capacity in specifically white muscle rather than red muscle. These data provide evidence that differences in white muscle may have a role in the divergent aerobic capacity observed in this generation of LCR/HCR.
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