Evidence map›Paper›PMID 21270230›Full record

ArticleJournal of clinical microbiology2011

Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpert MTB/RIF system.

Doris Hillemann, Sabine Rüsch-Gerdes, Catharina Boehme, Elvira Richter

Registry-linked trialAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02043080 (CIDRZ 1201 - Optimizing Clinical Outcomes in HIV-Infected Adults & Children Using Xpert MTB/RIF in Zambia), which is not on this map. Cited by 178 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02043080 nacompletednot on this mapstarted 2012, after this paper: background citation

CIDRZ 1201 - Optimizing Clinical Outcomes in HIV-Infected Adults & Children Using Xpert MTB/RIF in Zambia

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2012 to 2017Enrolled1,436ConditionsTuberculosis Diagnosis, HIVArmsXpert MTB/RIF Tuberculosis diagnostic tool
3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  6. XpertThe Cochrane database of systematic reviews · 2018
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Doris HillemannNationales Referenzzentrum für Mykobakterien, Forschungszentrum Borstel, Parkallee 18, 23845 Borstel, Germany. dhillemann@fz-borstel.de
Sabine Rüsch-Gerdes
Catharina Boehme
Elvira Richter

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In total, 521 nonrespiratory specimens (91 urine, 30 gastric aspirate, 245 tissue, 113 pleural fluid, 19 cerebrospinal fluid [CSF], and 23 stool specimens) submitted to the German National Reference Laboratory for Mycobacteria (NRL) from May 2009 to August 2010 were comparatively investigated with the new molecular-based GeneXpert MTB/RIF (Xpert) assay system and conventional liquid and solid culture methods. Twenty (3.8%) of the 521 specimens gave no interpretable result. Whereas the sensitivity of the Xpert assay with tissue specimens was 69.0% (20 out of 29 culture-positive cases detected), 100% sensitivity was found with the urine and stool specimens. The combined sensitivity and specificity of the Xpert assay were calculated to be 77.3% and 98.2%, respectively.

Indexed as

AutomationBacteriological TechniquesGermanyHumansMolecular Diagnostic TechniquesMycobacterium tuberculosisSensitivity and SpecificityTime FactorsTuberculosis

Identifiers

PMID21270230
PMCPMC3122824

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.