ArticleJournal of clinical microbiology2011
Multilocus sequence typing subtypes of poultry Clostridium perfringens isolates demonstrate disease niche partitioning.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Antimicrobial resistance and genetic characterization ofOne health (Amsterdam, Netherlands) · 2026Article
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- Genetic characterization of gut-associatedFrontiers in microbiology · 2026Article
- Genome MLST scheme for tracing genetic diversity and multidrug resistance of food animal-derivedCurrent research in food science · 2025Article
- Emergence of genetic diversity and multi-drug resistant Clostridium perfringens from wild birds.BMC veterinary research · 2024Article
- Pathogenicity and Antibiotic Resistance Diversity inPathogens (Basel, Switzerland) · 2023Article
- Antimicrobial susceptibility and multilocus sequence typing ofFrontiers in veterinary science · 2022Article
- Role ofVaccines · 2021Review
- Prevalence and multilocus sequence typing of Clostridium perfringens isolated from retail chicken products and diseased chickens in Tai'an region, China.Veterinary medicine and science · 2021Article
- Establishment of a Publicly Available Core Genome Multilocus Sequence Typing Scheme for Clostridium perfringens.Microbiology spectrum · 2021Article
- Bacteriological and molecular typing of Clostridium perfringens strains isolated in retail beef in Beijing, China.The Journal of veterinary medical science · 2021Article
- Investigation ofVeterinary world · 2021Article
- Prevalence and multilocus sequence typing of Clostridium perfringens isolated from 4 duck farms in Shandong province, China.Poultry science · 2020Article
- Large-Scale Genomic Analyses and Toxinotyping ofFrontiers in microbiology · 2019Article
- Gangrenous dermatitis in chickens and turkeys.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Review
- Commentary: Probing Genomic Aspects of the Multi-Host PathogenFrontiers in microbiology · 2018Article
- Conjugation-Mediated Horizontal Gene Transfer of Clostridium perfringens Plasmids in the Chicken Gastrointestinal Tract Results in the Formation of New Virulent Strains.Applied and environmental microbiology · 2017Article
- Recurring Necrotic Enteritis Outbreaks in Commercial Broiler Chicken Flocks Strongly Influence Toxin Gene Carriage and Species Richness in the ResidentFrontiers in microbiology · 2017Article
- Article
- Virulence Plasmids of Spore-Forming Bacteria.Microbiology spectrum · 2014Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium perfringens is a ubiquitous and versatile pathogenic bacterium and is implicated in the etiology of the poultry diseases necrotic enteritis (NE) and poultry gangrene (PG). In this study, multilocus sequence typing was used to investigate genotypic relationships among 139 C. perfringens isolates from 74 flocks. These isolates had multiple disease, host, and environmental origins. The results indicated a polymorphic yet highly clonal population, with 79.6% of all isolates partitioning into one of six clonal complexes or two dominant sequence types, ST-9 and ST-31. The most prolific clonal complex, CC-1, contained 27.3% of all isolates and was not clearly associated with one particular disease. The subtypes CC-4 and ST-31 were highly associated with NE and represented 9.4% and 7.2% of the total isolates, respectively. No PG-associated and NE-associated C. perfringens isolates shared the same sequence type or clonal complex. NE-associated subtypes were more clonal and appeared more evolutionarily divergent than PG-associated subtypes, which tended to cluster in the more ancestral lineages alongside isolates from asymptomatic chickens and turkeys. Toxin gene screening identified cpb2 throughout these isolates and correlated the presence of netB with NE pathology. Previous investigations into the genetic basis of C. perfringens pathogenicity have focused on toxins and other variable genetic elements. This study presents the first sequence-based comparison of C. perfringens isolates recovered in clinical cases of PG and NE and demonstrates that niche specialization is observable in the core genomes of poultry-associated C. perfringens isolates, a concept with both epidemiological and evolutionary significance.
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