ArticleJournal of virology2011
Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial.The Journal of clinical investigation · 2021Trial
- Brief Report: HIV-1 gp120 T-Cell Responses Correspond to Infection Outcomes in the Global iPrEx Chemoprophylaxis Trial.Journal of acquired immune deficiency syndromes (1999) · 2016Trial
- Regulatory T-Cell Activity But Not Conventional HIV-Specific T-Cell Responses Are Associated With Protection From HIV-1 Infection.Journal of acquired immune deficiency syndromes (1999) · 2016Trial
- Proteome-wide analysis of HIV-specific naive and memory CD4(+) T cells in unexposed blood donors.The Journal of experimental medicine · 2014Trial
- HIV-1-specific CD8PNAS nexus · 2025Article
- Low-Frequency, Sustained CD4 T-Cell Responses Chlamydia trachomatis in Women: Predominant Targeting of Chlamydial Proteaselike Activity Factor (CPAF).The Journal of infectious diseases · 2025Article
- HIV-1 protective epitope-specific CD8iScience · 2023Article
- Review
- Can T Cells Abort SARS-CoV-2 and Other Viral Infections?International journal of molecular sciences · 2023Review
- Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination.eLife · 2022Article
- Design and validation of HIV peptide pools for detection of HIV-specific CD4+ and CD8+ T cells.PloS one · 2022Article
- Elevated Numbers of HIV-Specific Poly-Functional CD8Frontiers in immunology · 2021Article
- Immune signatures for HIV-1 and HIV-2 induced CD4BMC infectious diseases · 2019Article
- Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to Infections.Frontiers in immunology · 2019Review
- Article
- Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.AIDS research and therapy · 2017Review
- Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Alternative effector-function profiling identifies broad HIV-specific T-cell responses in highly HIV-exposed individuals who remain uninfected.The Journal of infectious diseases · 2015Article
- Characterization of T-cell responses to cryptic epitopes in recipients of a noncodon-optimized HIV-1 vaccine.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Induction of Potent and Long-Lived Antibody and Cellular Immune Responses in the Genitorectal Mucosa Could be the Critical Determinant of HIV Vaccine Efficacy.Frontiers in immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
HIV-1-specific T lymphocyte responses in individuals exposed to HIV-1 but who remain persistently seronegative (HESNs) have been reported in some but not all previous studies. This study was designed to resolve unequivocally the question of whether HESNs make HIV-1-specific T cell responses. We performed a blind investigation to measure HIV-1-specific T cell responses in both HIV-1-serodiscordant couples and HIV-1-unexposed seronegative controls (HUSNs). We found low-frequency HIV-1-specific T cells in both HESNs and HUSNs but show that the response rates were higher over time in the former (P = 0.01). Furthermore, the magnitudes of the HIV-1-specific T cell responses were significantly higher among responding HESNs than among HUSNs over time (P = 0.002). In both groups, responses were mediated by CD4 T cells. The responses were mapped to single peptides, which often corresponded to epitopes restricted by multiple HLA-DR types that have previously been detected in HIV-1-infected patients. HIV-1-specific T cell responses in HUSNs and some HESNs likely represent cross-reactivity to self or foreign non-HIV-1 antigens. The significantly greater T cell responses in HESNs, including in two who were homozygous for CCR5Δ32, demonstrates that HIV-1-specific T cell responses can be induced or augmented by exposure to HIV-1 without infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.