ArticleJournal of virology2011
Replication of avocado sunblotch viroid in the yeast Saccharomyces cerevisiae.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Derailing the host machinery to achieve replication: how viroid and viroid-like RNAs successfully copy their genomes in hostile territory.RNA biology · 2025Review
- Diversity and evolution of viroids and viroid-like agents with circular RNA genomes revealed by metatranscriptome mining.Nucleic acids research · 2025Article
- No evidence for human or rodent deltavirus replication in yeast.microPublication biology · 2025Article
- Viroid Replication, Movement, and the Host Factors Involved.Microorganisms · 2024Review
- Cellular roadmaps of viroid infection.Trends in microbiology · 2023Review
- The intriguing phenomenon of cross-kingdom infections of plant and insect viruses to fungi: Can other animal viruses also cross-infect fungi?PLoS pathogens · 2023Article
- Pest categorisation of theEFSA journal. European Food Safety Authority · 2023Article
- First Detection of Potato Spindle Tuber Viroid in Natural Isolates of Potato Blight Agent Phytophthora infestans.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023Article
- Novel Viroid-Like RNAs Naturally Infect a Filamentous Fungus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
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- Modes of Viroid Transmission.Cells · 2022Review
- Viroids and Viroid-like Circular RNAs: Do They Descend from Primordial Replicators?Life (Basel, Switzerland) · 2022Article
- A scenario for the emergence of protoviroids in the RNA world and for their further evolution into viroids and viroid-like RNAs by modular recombinations and mutations.Virus evolution · 2022Review
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- Symptomatic plant viroid infections in phytopathogenic fungi: A request for a critical reassessment.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Symptomatic plant viroid infections in phytopathogenic fungi.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Full-Length Hairpin RNA Accumulates at High Levels in Yeast but Not in Bacteria and Plants.Genes · 2019Article
- Review
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viroids are the smallest known pathogenic agents. They are noncoding, single-stranded, closed-circular, "naked" RNAs, which replicate through RNA-RNA transcription. Viroids of the Avsunviroidae family possess a hammerhead ribozyme in their sequence, allowing self-cleavage during their replication. To date, viroids have only been detected in plant cells. Here, we investigate the replication of Avocado sunblotch viroid (ASBVd) of the Avsunviroidae family in a nonconventional host, the yeast Saccharomyces cerevisiae. We demonstrate that ASBVd RNA strands of both polarities are able to self-cleave and to replicate in a unicellular eukaryote cell. We show that the viroid monomeric RNA is destabilized by the nuclear 3' and the cytoplasmic 5' RNA degradation pathways. For the first time, our results provide evidence that viroids can replicate in other organisms than plants and that yeast contains all of the essential cellular elements for the replication of ASBVd.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.