ArticleThe Journal of allergy and clinical immunology2011
Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness.
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 105 citations in OpenAlex.
- Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial.European journal of clinical nutrition · 2016Trial
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- Drivers of Bronchodilator Use in Bronchiolitis: Analyzing Treatment Trends From Pediatric Emergency Department Practices.Pediatric emergency care · 2025Article
- The differential burden of acute rhinovirus infections in children with underlying conditions.PloS one · 2025Article
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- Navigating paediatric virology through the COVID‑19 era (Review).International journal of molecular medicine · 2023Review
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- Risk Factors Associated With Bronchiolitis in Puerto Rican Children.Pediatric emergency care · 2021Article
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- Rhinovirus Infection in Children with Acute Bronchiolitis and Its Impact on Recurrent Wheezing and Asthma Development.Microorganisms · 2020Review
- Genotypic diversity, circulation patterns and co-detections among rhinoviruses in Queensland, 2001.Access microbiology · 2020Article
- Rhinovirus Species in Children With Severe Bronchiolitis: Multicenter Cohort Studies in the United States and Finland.The Pediatric infectious disease journal · 2019Article
- Respiratory Viruses and Asthma.Seminars in respiratory and critical care medicine · 2018Review
- Simulation of four respiratory viruses and inference of epidemiological parameters.Infectious Disease Modelling · 2018Article
- Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013-2015.Frontiers in microbiology · 2018Article
- Rhinovirus species and clinical characteristics in the first wheezing episode in children.Journal of medical virology · 2016Article
- [An epidemiological study on human rhinovirus C in hospitalized children with respiratory tract infections].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Advancing our understanding of infant bronchiolitis through phenotyping and endotyping: clinical and molecular approaches.Expert review of respiratory medicine · 2016Review
- Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis.American journal of respiratory and critical care medicine · 2016Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRisk factors for severe human rhinovirus (HRV)-associated infant illness are unknown.
objectivesWe sought to examine the role of HRV infection in infant respiratory tract illness and assess viral and host risk factors for HRV-associated disease severity.
methodsWe used a prospective cohort of term, previously healthy infants enrolled during an inpatient or outpatient visit for acute upper or lower respiratory tract illness during the fall-spring months of 2004-2008. Illness severity was determined by using an ordinal bronchiolitis severity score, with higher scores indicating more severe disease. HRV was identified by means of real-time RT-PCR. The VP4/VP2 region from HRV-positive specimens was sequenced to determine species.
resultsOf 630 infants with bronchiolitis or upper respiratory tract illnesses (URIs), 162 (26%) had HRV infection; HRV infection was associated with 18% of cases of bronchiolitis and 47% of cases of URI. Among infants with HRV infection, 104 (64%) had HRV infection alone. Host factors associated with more severe HRV-associated illness included a maternal and family history of atopy (median score of 3.5 [interquartile range [IQR], 1.0-7.8] vs 2.0 [IQR, 1.0-5.2] and 3.5 [IQR, 1.0-7.5] vs 2.0 [IQR, 0-4.0]). In adjusted analyses maternal history of atopy conferred an increase in the risk for more severe HRV-associated bronchiolitis (odds ratio, 2.39; 95% CI, 1.14-4.99; P = .02). In a similar model maternal asthma was also associated with greater HRV-associated bronchiolitis severity (odds ratio, 2.49, 95% CI, 1.10-5.67; P = .03). Among patients with HRV infection, 35% had HRVA, 6% had HRVB, and 30% had HRVC.
conclusionHRV infection was a frequent cause of bronchiolitis and URIs among previously healthy term infants requiring hospitalization or unscheduled outpatient visits. Substantial viral genetic diversity was seen among the patients with HRV infection, and predominant groups varied by season and year. Host factors, including maternal atopy, were associated with more severe infant HRV-associated illness.
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