SynthesisBMC gastroenterology2011
Helicobacter pylori infection and circulating ghrelin levels - a systematic review.
Synthesis in BMC gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Association betweenBMJ open · 2020Pooled it
- Pooled it
- Nigella sativa powder for helicobacter pylori infected patients: a randomized, double-blinded, placebo-controlled clinical trial.BMC complementary medicine and therapies · 2023Trial
- Interaction Between Metabolic Diseases, GLP-1 Receptor Agonists, and Helicobacter pylori Infection: An Updated Evidence Summary.The Korean journal of helicobacter and upper gastrointestinal research · 2026Article
- Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview.Recent advances in food, nutrition & agriculture · 2025Review
- Effect ofChildren (Basel, Switzerland) · 2024Article
- Therapeutic potential of ghrelin/GOAT/GHSR system in gastrointestinal disorders.Frontiers in nutrition · 2024Review
- Effect ofJournal of neurogastroenterology and motility · 2023Article
- Clinical and endoscopic study of dyspepsia in overweight and obese patients.Journal of family medicine and primary care · 2022Article
- Overview ofDiseases (Basel, Switzerland) · 2021Review
- Impact of Dietary Patterns onPathogens (Basel, Switzerland) · 2021Review
- Gut Microbiota: The Missing Link BetweenFrontiers in endocrinology · 2021Review
- Effect of Helicobacter Pylori Infection on Nutritional Status in Polish Teenagers.Gastroenterology research and practice · 2021Article
- Verrucous antral gastritis in relation toGastroenterology report · 2020Article
- Impact of a Fermented High-Fiber Rye Diet onFrontiers in nutrition · 2020Article
- Association between Helicobacter pylori infection, eradication and diabetes mellitus.Journal of diabetes investigation · 2019Article
- Acylated ghrelin levels were associated with depressive status, physical quality of life, endoscopic findings based on Kyoto classification in Japan.Journal of clinical biochemistry and nutrition · 2019Article
- Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice.Scientific reports · 2019Article
- Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis.World journal of gastroenterology · 2019Review
- The need for a patient-tailored Helicobacter pylori eradication protocol prior to bariatric surgery.The Journal of international medical research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe nature of the association between ghrelin, an orexigenic hormone produced mainly in the stomach, and Helicobacter pylori (H pylori), a bacterium that colonises the stomach, is still controversial. We examined available evidence to determine whether an association exists between the two; and if one exists, in what direction.
methodsWe reviewed original English language studies on humans reporting circulating ghrelin levels in H pylori infected and un-infected participants; and circulating ghrelin levels before and after H pylori eradication. Meta-analyses were conducted for eligible studies by combining study specific estimates using the inverse variance method with weighted average for continuous outcomes in a random effects model.
resultsSeventeen out of 27 papers that reported ghrelin levels in H pylori positive and negative subjects found lower circulating ghrelin levels in H pylori positive subjects; while 10 found no difference. A meta-analysis of 19 studies with a total of 1801 participants showed a significantly higher circulating ghrelin concentration in H pylori negative participants than in H pylori positive participants (Effect estimate (95%CI) = -0.48 (-0.60, -0.36)). However, eradicating H pylori did not have any significant effect on circulating ghrelin levels (Effect estimate (95% CI) = 0.08 (-0.33, 0.16); Test for overall effect: Z = 0.67 (P = 0.5)).
conclusionsWe conclude that circulating ghrelin levels are lower in H pylori infected people compared to those not infected; but the relationship between circulating ghrelin and eradication of H pylori is more complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.