ArticleBMC gastroenterology2011
Effect of childbirth on the course of Crohn's disease; results from a retrospective cohort study in the Netherlands.
Article in BMC gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Vaginal delivery in women with perianal Crohn's disease: why not?AJOG global reports · 2024Article
- The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease.BMC gastroenterology · 2024Article
- Inflammatory bowel disease in pregnancy and breastfeeding.Nature reviews. Gastroenterology & hepatology · 2023Review
- Review of pregnancy in Crohn's disease and ulcerative colitis.Therapeutic advances in gastroenterology · 2021Review
- Mode of childbirth and long-term outcomes in women with inflammatory bowel diseases.Digestive diseases and sciences · 2015Article
- Magnetic resonance enterography in pregnant women with Crohn's disease: case series and literature review.BMC gastroenterology · 2014Review
- Impact of mode of delivery on outcomes in patients with perianal Crohn's disease.Inflammatory bowel diseases · 2014Article
- From conception to delivery: managing the pregnant inflammatory bowel disease patient.World journal of gastroenterology · 2014Review
- Vaginoperineal Fistula as a Complication of Perianal Surgery in a Patient with Sjögren's Syndrome: A Case Report.Case reports in rheumatology · 2014Article
- Crohn's disease in women.International journal of women's health · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnant women with Crohn's disease needs proper counselling about the effect of pregnancy and childbirth on their disease. However, Literature about the effect of childbirth on Crohn's disease is limited. This study examined the effect of childbirth on the course of Crohn's disease and especially perianal Crohn's disease.
methodsThis is a retrospective cohort study which was performed in a tertiary level referral hospital in the Netherlands. From the IBD database, female patients aged 18-80 years in 2004 were selected. Data analysis took place in the years 2005 and 2006. Eventually, 114 women with at least one pregnancy after the diagnosis of Crohn's disease were eligible for the study. Differences between groups were analyzed using Wilcoxon Mann Whitney tests and Chi-square analysis with 2 × 2 or 2 × 3 contingency tables. Two-tailed values were used and p values < 0.05 were considered statistically significant.
results21/114 women (18%) had active luminal disease prior to pregnancy, with significantly more pregnancy related complications compared to women with inactive luminal disease (Odds ratio 2.8; 95% CI 1.0 - 7.4). Caesarean section rate was relatively high (37/114, 32%), especially in patients with perianal disease prior to pregnancy compared to women without perianal disease (Odds ratio 4.6; 95% CI 1.8 - 11.4). Disease progression after childbirth was more frequent in patients with active luminal disease prior to pregnancy compared to inactive luminal disease (Odds ratio 9.7; 95% CI 2.1 - 44.3). Progression of perianal disease seems less frequent after vaginal delivery compared with caesarean section, in both women with prior perianal disease (18% vs. 31%, NS) and without prior perianal disease (5% vs 14%, NS). There were no more fistula-related complications after childbirth in women with an episiotomy or second degree tear.
conclusionA relatively high rate of caesarean sections was observed in women with Crohn's disease, especially in women with perianal disease prior to pregnancy. A protective effect of caesarean section on progression of perianal disease was not observed. However, this must be interpreted carefully due to confounder effect by indication for caesarean section.
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