ArticleBMC systems biology2011
Initial characterization of the human central proteome.
Article in BMC systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
- Proteomic Analysis of Serum in Cardiac Transthyretin Amyloidosis: Diagnostic and Prognostic Implications for Biomarker Discovery.Biomedicines · 2025Article
- Combining Quantitative Proteomics and Interactomics for a Deeper Insight into Molecular Differences between Human Cell Lines.Journal of proteome research · 2024Article
- Combining quantitative proteomics and interactomics for a deeper insight into molecular differences between human cell lines.bioRxiv : the preprint server for biology · 2024Article
- Proteomics reveals specific biological changes induced by the normothermic machine perfusion of donor kidneys with a significant up-regulation of Latexin.Scientific reports · 2023Article
- Polypeptide N-acetylgalactosamine transferase 3: a post-translational writer on human health.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Analysis of transcription profile to reveal altered signaling pathways following the overexpression of human desumoylating isopeptidase 2 in pancreatic cancer cells.Oncology letters · 2016Article
- Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature.Oncotarget · 2016Article
- MoCps1 is important for conidiation, conidial morphology and virulence in Magnaporthe oryzae.Current genetics · 2016Article
- Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.Nature communications · 2016Article
- Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.Scientific reports · 2016Article
- Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease.Nucleic acids research · 2016Article
- Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.Nature methods · 2015Article
- High spatial resolution proteomic comparison of the brain in humans and chimpanzees.The Journal of comparative neurology · 2015Article
- Article
- Understanding multicellular function and disease with human tissue-specific networks.Nature genetics · 2015Article
- Proteome sequencing goes deep.Current opinion in chemical biology · 2015Review
- Proteomic Study to Survey the CIGB-552 Antitumor Effect.BioMed research international · 2015Article
- Building and exploring an integrated human kinase network: global organization and medical entry points.Journal of proteomics · 2014Article
- Protein conservation and variation suggest mechanisms of cell type-specific modulation of signaling pathways.PLoS computational biology · 2014Article
- Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOn the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and properties of the central proteome are investigated through bioinformatics analyses.
resultsWe experimentally identify a central proteome comprising 1,124 proteins that are ubiquitously and abundantly expressed in human cells using state of the art mass spectrometry and protein identification bioinformatics. The main represented functions are proteostasis, primary metabolism and proliferation. We further characterize the central proteome considering gene structures, conservation, interaction networks, pathways, drug targets, and coordination of biological processes. Among other new findings, we show that the central proteome is encoded by exon-rich genes, indicating an increased regulatory flexibility through alternative splicing to adapt to multiple environments, and that the protein interaction network linking the central proteome is very efficient for synchronizing translation with other biological processes. Surprisingly, at least 10% of the central proteome has no or very limited functional annotation.
conclusionsOur data and analysis provide a new and deeper description of the human central proteome compared to previous results thereby extending and complementing our knowledge of commonly expressed human proteins. All the data are made publicly available to help other researchers who, for instance, need to compare or link focused datasets to a common background.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.