ArticleACS chemical biology2011
Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein.
Article in ACS chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Elucidating the Iterative Elongation Mechanism in a Type III Polyketide Synthase.Journal of the American Chemical Society · 2025Article
- Fluorometric Analysis of Carrier-Protein-Dependent Biosynthesis through a Conformationally Sensitive Solvatochromic Pantetheinamide Probe.ACS chemical biology · 2024Article
- Enzymology of standalone elongating ketosynthases.Chemical science · 2022Review
- Trapping the Complex Molecular Machinery of Polyketide and Fatty Acid Synthases with Tunable Silylcyanohydrin Crosslinkers.Angewandte Chemie (International ed. in English) · 2018Article
- Type II fatty acid and polyketide synthases: deciphering protein-protein and protein-substrate interactions.Natural product reports · 2018Review
- Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.Methods in enzymology · 2018Article
- Manipulating Protein-Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins.Biochemistry · 2017Article
- Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction.Journal of the American Chemical Society · 2016Article
- Recognition of extended linear and cyclised polyketide mimics by a type II acyl carrier protein.Chemical science · 2016Article
- Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.Journal of the American Chemical Society · 2015Article
- Modeling linear and cyclic PKS intermediates through atom replacement.Journal of the American Chemical Society · 2014Article
- Chemoenzymatic exchange of phosphopantetheine on protein and peptide.Chemical science · 2014Article
- The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.Natural product reports · 2014Review
- Resin supported acyl carrier protein labeling strategies.RSC advances · 2014Article
- Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors.The Journal of antibiotics · 2014Article
- Sulfonyl 3-alkynyl pantetheinamides as mechanism-based cross-linkers of acyl carrier protein dehydratase.Journal of the American Chemical Society · 2013Article
- Reversible labeling of native and fusion-protein motifs.Nature methods · 2012Article
- Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli.Bioorganic & medicinal chemistry · 2012Article
- Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway.Biochemistry · 2011Article
- Probing the structure and function of acyl carrier proteins to unlock the strategic redesign of type II polyketide biosynthetic pathways.The Journal of biological chemistryReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Type II polyketide synthases are biosynthetic enzymatic pathways responsible for the production of complex aromatic natural products with important biological activities. In these systems, biosynthetic intermediates are covalently bound to a small acyl carrier protein that associates with the synthase enzymes and delivers the bound intermediate to each active site. In the closely related fatty acid synthases of bacteria and plants, the acyl carrier protein acts to sequester and protect attached intermediates within its helices. Here we investigate the type II polyketide synthase acyl carrier protein from the actinorhodin biosynthetic pathway and demonstrate its ability to internalize the tricyclic, polar molecule emodic acid. Elucidating the interaction of acyl carrier proteins with bound analogues resembling late-stage intermediates in the actinorhodin pathway could prove valuable in efforts to engineer these systems toward rational design and biosynthesis of novel compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.