ArticleJournal of the American Chemical Society2011
Selective enhancement of nucleases by polyvalent DNA-functionalized gold nanoparticles.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 125 citations in OpenAlex.
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- Metal nanoparticles as inhibitors of enzymes and toxins of multidrug-resistantInfectious medicine · 2023Review
- Unraveling the Possibilities: Recent Progress in DNA Biosensing.Biosensors · 2023Review
- Magnetically Assisted Immobilization-Free Detection of microRNAs Based on the Signal Amplification of Duplex-Specific Nuclease.Biosensors · 2023Article
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- DNA Nanostructures and DNA-Functionalized Nanoparticles for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- The effector mechanism of siRNA spherical nucleic acids.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Exploration of the nanomedicine-design space with high-throughput screening and machine learning.Nature biomedical engineering · 2019Article
- Dual Toll-Like Receptor Targeting Liposomal Spherical Nucleic Acids.Bioconjugate chemistry · 2019Article
- Precision Tuning of DNA- and Poly(ethylene glycol)-Based Nanoparticles via Coassembly for Effective Antisense Gene Regulation.Chemistry of materials : a publication of the American Chemical Society · 2017Article
- A Broadly Applicable Assay for Rapidly and Accurately Quantifying DNA Surface Coverage on Diverse Particles.Bioconjugate chemistry · 2017Article
- Controlling DNA-nanoparticle serum interactions.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Polyvalent Catalysts Operating on Polyvalent Substrates: A Model for Surface-Controlled Reactivity.Angewandte Chemie (International ed. in English) · 2016Article
- Electrocatalytic amplification of DNA-modified nanoparticle collisionsChemical science · 2016Article
- A molecular nanodevice for targeted degradation of mRNA during protein synthesis.Scientific reports · 2016Article
- Application of a nanoflare probe specific to a latency associated transcript for isolation of KHV latently infected cells.Virus research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We demonstrate that polyvalent DNA-functionalized gold nanoparticles (DNA-Au NPs) selectively enhance ribonuclease H (RNase H) activity while inhibiting most biologically relevant nucleases. This combination of properties is particularly interesting in the context of gene regulation, since high RNase H activity results in rapid mRNA degradation and general nuclease inhibition results in high biological stability. We have investigated the mechanism of selective RNase H activation and found that the high DNA density of DNA-Au NPs is responsible for this unusual behavior. This work adds to our understanding of polyvalent DNA-Au NPs as gene regulation agents and suggests a new model for selectively controlling protein-nanoparticle interactions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.