ArticleJournal of cellular biochemistry2011
An autonomous BMP2 regulatory element in mesenchymal cells.
Article in Journal of cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.Genesis (New York, N.Y. : 2000) · 2017Article
- Competing Repressive Factors Control Bone Morphogenetic Protein 2 (BMP2) in Mesenchymal Cells.Journal of cellular biochemistry · 2016Article
- Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells.Journal of cellular biochemistry · 2015Review
- Dynamics and cellular localization of Bmp2, Bmp4, and Noggin transcription in the postnatal mouse skeleton.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Bone morphogenetic protein-focused strategies to induce cytotoxicity in lung cancer cells.Anticancer research · 2014Article
- Skeletal trauma generates systemic BMP2 activation that is temporally related to the mobilization of CD73+ cells.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2014Article
- An in vivo map of bone morphogenetic protein 2 post-transcriptional repression in the heart.Genesis (New York, N.Y. : 2000) · 2011Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
BMP2 is a morphogen that controls mesenchymal cell differentiation and behavior. For example, BMP2 concentration controls the differentiation of mesenchymal precursors into myocytes, adipocytes, chondrocytes, and osteoblasts. Sequences within the 3'untranslated region (UTR) of the Bmp2 mRNA mediate a post-transcriptional block of protein synthesis. Interaction of cell and developmental stage-specific trans-regulatory factors with the 3'UTR is a nimble and versatile mechanism for modulating this potent morphogen in different cell types. We show here, that an ultra-conserved sequence in the 3'UTR functions independently of promoter, coding region, and 3'UTR context in primary and immortalized tissue culture cells and in transgenic mice. Our findings indicate that the ultra-conserved sequence is an autonomously functioning post-transcriptional element that may be used to modulate the level of BMP2 and other proteins while retaining tissue specific regulatory elements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.