ReviewBiopolymers2011
Forcing a connection: impacts of single-molecule force spectroscopy on in vivo tension sensing.
Review in Biopolymers, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Mechanosensitive Ion Channels: The Unending Riddle of Mechanotransduction.Bioelectricity · 2025Review
- Insights into intercellular receptor-ligand binding kinetics in cell communication.Frontiers in bioengineering and biotechnology · 2022Review
- Focal Adhesion Kinase: The Reversible Molecular Mechanosensor.Biophysical journal · 2017Article
- Integrated magnetic tweezers and single-molecule FRET for investigating the mechanical properties of nucleic acid.Methods (San Diego, Calif.) · 2016Article
- ATP dependent NS3 helicase interaction with RNA: insights from molecular simulations.Nucleic acids research · 2015Article
- Measurement of subcellular force generation in neurons.Biophysical journal · 2015Article
- Ultrafast redistribution of E. coli SSB along long single-stranded DNA via intersegment transfer.Journal of molecular biology · 2014Article
- How cells feel: stochastic model for a molecular mechanosensor.Biophysical journal · 2014Article
- Membrane elastic properties and cell function.PloS one · 2013Article
- Force mapping during the formation and maturation of cell adhesion sites with multiple optical tweezers.PloS one · 2013Article
- Measuring intermolecular rupture forces with a combined TIRF-optical trap microscope and DNA curtains.Biochemical and biophysical research communications · 2012Article
- Combined versatile high-resolution optical tweezers and single-molecule fluorescence microscopy.The Review of scientific instruments · 2012Article
- Molecular force transduction by ion channels: diversity and unifying principles.Journal of cell science · 2012Review
- Microneedle-based analysis of the micromechanics of the metaphase spindle assembled in Xenopus laevis egg extracts.Nature protocols · 2012Article
- Biological mechanisms, one molecule at a time.Genes & development · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mechanical tension plays a large role in cell development ranging from morphology to gene expression. On the molecular level, the effects of tension can be seen in the dynamic arrangement of membrane proteins as well as the recruitment and activation of intracellular proteins. Forces applied to biopolymers during in vitro force measurements offer greater understanding of the effects of tension on molecules in live cells, and experimental techniques involving test tubes and live cells can often overlap. Indeed, when forces exerted on cellular components can be calibrated ex vivo with force spectroscopy, a powerful tool is available for researchers in probing cellular mechanotransduction on the molecular scale. This review will discuss the techniques used in measuring both cellular traction forces and single-molecule force spectroscopy. Emphasis will be placed on the use of fluorescence reporter systems for the development of in vivo tension sensors that can be used for calibration with single molecule force methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.