ArticleDocumenta ophthalmologica. Advances in ophthalmology2011
On and off responses of the photopic fullfield ERG in normal subjects and glaucoma patients.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Sustained Plus Lens Defocus Alters Retinal Responses and Ciliary Muscle Morphology In Myopes and Near-emmetropes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Selective i-wave attenuation in unilateral high myopia.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Glaucoma Classification Through SSVEP-Derived ON- and OFF-Pathway Features.Translational vision science & technology · 2026Article
- Evaluating Increment and Decrement Stimuli Responses in Patients with Glaucoma Using Virtual Reality-Based Perimetry.Ophthalmology science · 2026Article
- Impact of Myopia on the Utility of the Photopic Negative Response Ratio for Glaucoma Assessment.Journal of clinical medicine · 2025Article
- Electroretinographic responses to periodic stimuli in primates and the relevance for visual perception and for clinical studies.Visual neuroscience · 2024Review
- Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage.Translational vision science & technology · 2023Article
- Preferential Loss of Contrast Decrement Responses in Human Glaucoma.Investigative ophthalmology & visual science · 2022Article
- Asymmetric Functional Impairment of ON and OFF Retinal Pathways in Glaucoma.Ophthalmology science · 2021Article
- The photopic negative response (PhNR): measurement approaches and utility in glaucoma.International ophthalmology · 2020Review
- Probing ON and OFF Retinal Pathways in Glaucoma Using Electroretinography.Translational vision science & technology · 2020Review
- Electroretinogram of the Cone-Dominant Thirteen-Lined Ground Squirrel during Euthermia and Hibernation in Comparison with the Rod-Dominant Brown Norway Rat.Investigative ophthalmology & visual science · 2020Article
- Electoretinographic evidence of retinal ganglion cell-dependent function in schizophrenia.Schizophrenia research · 2020Article
- Comparison of the uniform-field electroretinogram and the pattern electroretinogram to checkerboard and bar gratings.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Optimizing a Portable ERG Device for Glaucoma Clinic: The Effect of Interstimulus Frequency on the Photopic Negative Response.Translational vision science & technology · 2018Article
- Baseline Detrending for the Photopic Negative Response.Translational vision science & technology · 2018Article
- ISCEV extended protocol for the photopic On-Off ERG.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- Reduction on OFF-responses of Electroretinogram in Monkeys with Long-term High Intraocular Pressure.Chinese medical journal · 2017Article
- Intensity response function of the photopic negative response (PhNR): effect of age and test-retest reliability.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Photopic negative response in diagnosis of glaucoma: an experimental study in glaucomatous rabbit model.International journal of ophthalmology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggest a diagnostic value of the photopic negative response (PhNR) with a long-duration stimulus. The aim of this study was to record the on and off responses of the photopic fullfield electroretinogram (ERG) in normal subjects and glaucoma patients. We focused on different waves of the responses after onset and offset of the long-duration stimulus ERG. Photopic fullfield ERGs were recorded in response to a white bright LED flash on a white 20 cd/m(2) background. Stimulus luminances were 40, 60 and 80 cd/m(2). Responses were averaged using a flash duration of 240 ms and an offset period of 500 ms. We examined 19 healthy subjects, 27 patients with glaucomatous optic disc atrophy and 7 ocular hypertensive patients. The amplitudes and implicit times of the on and off responses of the human ERG depended on flash luminance. Comparing patients with glaucoma and healthy subjects for the 60 cd/m² flash, there was a significant change in the PhNRs (at onset: P < 0.01, at offset: P < 0.001) of the d-wave and of the i-wave at offset (P < 0.01). No significant difference was found for peak times of the fullfield ERG and for a- and b-wave amplitudes. PhNR amplitudes were significantly correlated with mean thickness of retinal nerve fibre layer as measured with OCT. In comparison with the normal photopic long-flash ERG, glaucoma patients showed changes in the PhNR amplitude following stimulus onset and in waves following stimulus offset.
Indexed as
Identifiers
21267627What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.