ArticleHeart and vessels2011
In patients with idiopathic venous thrombosis, interleukin-10 is decreased and related to endothelial dysfunction.
Article in Heart and vessels, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Search for Venous Endothelial Biomarkers Heralding Venous Thromboembolism in Space: A Qualitative Systematic Review of Terrestrial Studies.Frontiers in physiology · 2022Pooled it
- Inflammation-A Link Between Arterial Atherosclerotic and Venous Thromboembolic Diseases.Cells · 2025Review
- The Link between Arterial Atherosclerotic Disease and Venous Thromboembolic Disease.Current vascular pharmacology · 2025Review
- A prognostic nomogram for recurrence survival in post-surgical patients with varicose veins of the lower extremities.Scientific reports · 2024Article
- Heparin-induced thrombocytopenia-II in hospitalized patients with surgery or deep vein thrombosis.American journal of blood research · 2024Article
- Dynamic observation of circRNA and mRNA profiles in a rat model of deep vein thrombosis.Experimental and therapeutic medicine · 2023Article
- Association between inflammatory biomarkers and venous thromboembolism: a systematic review and meta-analysis.Thrombosis journal · 2023Review
- Pathophysiology of deep vein thrombosis.Clinical and experimental medicine · 2023Review
- Venous stroke-a stroke subtype that should not be ignored.Frontiers in neurology · 2022Review
- Thrombo-inflammatory biomarkers and D-dimer in a biracial cohort study.Research and practice in thrombosis and haemostasis · 2021Article
- Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation.International journal of molecular sciences · 2021Article
- COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness.Journal of thrombosis and thrombolysis · 2021Review
- From Classical Laboratory Parameters to Novel Biomarkers for the Diagnosis of Venous Thrombosis.International journal of molecular sciences · 2020Review
- In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate.Archives of medical science : AMS · 2019Article
- Eosinophilic biomarkers for detection of acute exacerbation of chronic obstructive pulmonary disease with or without pulmonary embolism.Experimental and therapeutic medicine · 2017Article
- Successful reduction of inflammatory responses and arachidonic acid-cyclooxygenase 2 pathway in human pulmonary artery endothelial cells by silencing adipocyte fatty acid-binding protein.Journal of inflammation (London, England) · 2017Article
- The assessment of proinflammatory cytokines in the patients with the history of cerebral venous sinus thrombosis.Iranian journal of neurology · 2016Article
- Cross-sectional Study of Patients with Diffuse Large B-Cell Lymphoma: Assessing the Effect of Host Status, Tumor Burden, and Inflammatory Activity on Venous Thromboembolism.Cancer research and treatment · 2016Article
- Impact of advanced age on the severity of normotensive pulmonary embolism.Heart and vessels · 2015Article
- Inflammatory profile in subcutaneous and epicardial adipose tissue in men with and without diabetes.Heart and vessels · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the levels of anti-inflammatory interleukin-10 and pro-inflammatory cytokines and their relationship to endothelial function in patients with idiopathic venous thrombosis. Forty-nine eligible patients of both sexes with idiopathic venous thrombosis and 48 matched control subjects were studied. Levels of inflammatory markers were determined. Endothelial function was evaluated by ultrasound measurement of the flow mediated dilatation (FMD) of the brachial artery. Compared to the control group, patients with idiopathic venous thrombosis had significantly lower levels of interleukin-10 1.81 pg/ml (1.53-2.21) versus 2.71 pg/ml (1.84-3.65), p < 0.001. Patients also had increased levels of pro-inflammatory cytokines: interleukin-6 2.37 pg/ml (1.59-4.09) versus 2.03 pg/ml (1.49-2.59), p = 0.025, interleukin-8 3.53 pg/ml (2.94-5.30) versus 2.25 pg/ml (1.77-2.90), p < 0.001. Furthermore, decreased FMD was observed in patients: 5.0% (3.9-6.9) versus 12.7% (10.8-15.6), p < 0.001. FMD was related to levels of interleukin-10 (r = 0.33, p = 0.001) and was inversely related to pro-inflammatory cytokines interleukin-6 (r = -0.34, p = 0.001) and interleukin-8 (r = -0.43, p < 0.001). Patients with idiopathic venous thrombosis have decreased levels of IL-10 and increased levels of pro-inflammatory cytokines. This imbalance indicates that in the stable phase of the disease, patients have an increased systemic inflammatory response. This inflammatory response could be the consequence of the disease, but most probably is involved in the pathogenesis of venous thrombosis.
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