ReviewSeminars in immunopathology2011
Polyethylene and metal wear particles: characteristics and biological effects.
Review in Seminars in immunopathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Highly crosslinked polyethylene does not reduce aseptic loosening in cemented THA 10-year findings of a randomized study.Clinical orthopaedics and related research · 2012Trial
- Chemical, Mechanical and Tribological Effects of Artificially Aging up to 6 Weeks on Virgin and Crosslinked UHMWPE Evaluated for a TKR Design.Bioengineering (Basel, Switzerland) · 2025Article
- Macrophage phenotypes modulate neoangiogenesis and fibroblast profiles in synovial-like organoid cultures.Osteoarthritis and cartilage · 2025Article
- Review
- Introduction of innovations in joint arthroplasty: Recommendations from the 'EFORT implant and patient safety initiative'.EFORT open reviews · 2023Review
- Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Titanium Wear Particles ExacerbateMicroorganisms · 2021Article
- The Expression Levels of Toll-like Receptors after Metallic Particle and Ion Exposition in the Synovium of a Murine Model.Journal of clinical medicine · 2021Article
- Amorphous Carbon Coatings for Total Knee Replacements-Part II: Tribological Behavior.Polymers · 2021Article
- The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles.Biomedicines · 2021Article
- Estimation of the effects of inset heights and slit configurations in an acetabular cup on the pull-out behavior of an artificial hip joint with a structure for preventing dislocation using finite element analysis.Medical & biological engineering & computing · 2020Article
- Investigation of CoCrMo material loss in a novel bio-tribometer designed to study direct cell reaction to wear and corrosion products.Biotribology (Oxford) · 2019Article
- Article
- Local Biological Reactions and Pseudotumor-Like Tissue Formation in relation to Metal Wear in a Murine In Vivo Model.BioMed research international · 2019Article
- Differential Effect of Cobalt and Chromium Ions as Well as CoCr Particles on the Expression of Osteogenic Markers and Osteoblast Function.International journal of molecular sciences · 2018Article
- Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes.Seminars in diagnostic pathology · 2018Review
- Article
- Impact of vitamin E-blended UHMWPE wear particles on the osseous microenvironment in polyethylene particle-induced osteolysis.International journal of molecular medicine · 2016Article
- [Supramacroparticulate polyethylene in inflammation of synovial-like interface membranes: Characterization and suggested nomenclature].Der Orthopade · 2016Article
- Evaluation of impingement behaviour in lumbar spinal disc arthroplasty.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper first presents a brief overview about the mechanism of wear particle formation as well as wear particle characteristics in metal-on-polyethylene and metal-on-metal artificial hip joints. The biological effects of such particles are then described, focusing on the inflammatory response induced by each type of particles as well as on how metal wear products may be the source of a T lymphocyte-mediated specific immune response, early adverse tissue responses, and genotoxicity. Finally, some of the current in vivo models used for the analysis of tissue response to various wear particles are presented.
Indexed as
Identifiers
21267569What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.