ArticleExperimental brain research2011
Role of the rostral ventrolateral medulla (RVLM) in the patterning of vestibular system influences on sympathetic nervous system outflow to the upper and lower body.
Article in Experimental brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Strengthening sleep-autonomic interaction via acoustic enhancement of slow oscillations.Sleep · 2019Trial
- Heart Meets Brain: Insights into Neurocardiac Pathophysiology.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Single-nucleus RNA sequencing reveals Cntnap2Journal of advanced research · 2026Article
- Control of Blood Pressure Variability Across Behavioral States by Brainstem Adrenergic Neurons.Circulation research · 2026Article
- Responses of neurons in the rostral ventrolateral medulla of conscious cats to anticipated and passive movements.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Vestibular neurons with direct projections to the solitary nucleus in the rat.Journal of neurophysiology · 2019Article
- Deciphering the Neural Control of Sympathetic Nerve Activity: Status Report and Directions for Future Research.Frontiers in neuroscience · 2017Review
- Obesity-Induced Hypertension: Brain Signaling Pathways.Current hypertension reports · 2016Review
- A Model of Blood Pressure, Heart Rate, and Vaso-Vagal Responses Produced by Vestibulo-Sympathetic Activation.Frontiers in neuroscience · 2016Article
- Recent advances in orthostatic hypotension presenting orthostatic dizziness or vertigo.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Review
- Melanocortinergic circuits from medial vestibular nuclei to the kidney defined by transneuronal transport of pseudorabies virus.International journal of clinical and experimental pathology · 2015Article
- Vestibulo-sympathetic responses.Comprehensive Physiology · 2014Review
- Retrograde tracing of medial vestibular nuclei connections to the kidney in mice.International journal of clinical and experimental pathology · 2014Article
- Additive role of the vestibular end organ and baroreceptors on the regulation of blood pressure in rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Vestibular-mediated synaptic inputs and pathways to sympathetic preganglionic neurons in the neonatal mouse.The Journal of physiology · 2012Article
- Collateralization of projections from the rostral ventrolateral medulla to the rostral and caudal thoracic spinal cord in felines.Experimental brain research · 2012Article
- Responses of neurons in the rostral ventrolateral medulla to whole body rotations: comparisons in decerebrate and conscious cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Research on animal models as well as human subjects has demonstrated that the vestibular system contributes to regulating the distribution of blood in the body through effects on the sympathetic nervous system. Elimination of vestibular inputs results in increased blood flow to the hindlimbs during vestibular stimulation, because it attenuates the increase in vascular resistance that ordinarily occurs in the lower body during head-up tilts. Additionally, the changes in vascular resistance produced by vestibular stimulation differ between body regions. Electrical stimulation of vestibular afferents produces an inhibition of most hindlimb vasoconstrictor fibers and a decrease in hindlimb vascular resistance, but an initial excitation of most upper body vasoconstrictor fibers accompanied by an increase in upper body vascular resistance. The present study tested the hypothesis that neurons in the principal vasomotor region of the brainstem, the rostral ventrolateral medulla (RVLM), whose projections extended past the T10 segment, to spinal levels containing sympathetic preganglionic neurons regulating lower body blood flow, respond differently to electrical stimulation of the vestibular nerve than RVLM neurons whose axons terminate rostral to T10. Contrary to our hypothesis, the majority of RVLM neurons were excited by vestibular stimulation, despite their level of projection in the spinal cord. These findings indicate that the RVLM is not solely responsible for establishing the patterning of vestibular-sympathetic responses. This patterning apparently requires the integration by spinal circuitry of labyrinthine signals transmitted from the brainstem, likely from regions in addition to the RVLM.
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