ArticlePloS one2011
Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Exposure to Circadian Disruption During Adolescence Interacts With a Genetic Risk Factor to Modify Schizophrenia-relevant Behaviors in a Sex-dependent Manner.Journal of biological rhythms · 2022Article
- Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone.NPJ schizophrenia · 2018Article
- Sleep/Wake Disruption in a Mouse Model of BLOC-1 Deficiency.Frontiers in neuroscience · 2018Article
- TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels.The Journal of biological chemistry · 2017Article
- Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation.Cell discovery · 2015Article
- Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus.The Journal of biological chemistry · 2014Article
- Behavioral characterization of mice overexpressing human dysbindin-1.Molecular brain · 2014Article
- Article
- In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise.Molecular psychiatry · 2013Review
- SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory.The European journal of neuroscience · 2012Article
- Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade.ASN neuro · 2011Review
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic variations in the gene encoding dysbindin has consistently been associated with schizophrenia and bipolar disorder, although little is known about the neural functions carried out by dysbindin. To gain some insight into this area, we took advantage of the readily available dysbindin-null mouse sandy (sdy-/-) and studied hippocampal neurogenesis using thymidine analogue bromodeoxuridine (BrdU). No significant differences were found in the proliferation (4 hours) or survival (1, 4 and 8 weeks after the last BrdU injection) of progenitors in the subgranular regions of the dentate gyrus between sdy-/- and sdy+/+ (control) mice. However, 4 weeks after the last BrdU injection, a significant reduction was observed in the ratio of neuronal differentiation in sdy-/- when compared to that of sdy+/+ (sdy+/+ = 87.0 ± 5.3% vs. sdy-/- = 71.3 ± 8.3%, p = 0.01). These findings suggest that dysbindin plays a role during differentiation process in the adult hippocampal neurogenesis and that its deficit may negatively affect neurogenesis-related functions such as cognition and mood.
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