ArticlePloS one2011
Ultradian cortisol pulsatility encodes a distinct, biologically important signal.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- The Burden of Preoperative Stress: Biological Mechanisms and Postoperative Outcomes.Brain sciences · 2026Review
- Current Challenges and Future Directions in the Assessment of Glucocorticoid Status.Endocrine reviews · 2024Review
- Modified Wavelet Analyses Permit Quantification of Dynamic Interactions Between Ultradian and Circadian Rhythms.Journal of biological rhythms · 2022Article
- Circadian rhythms and the HPA axis: A systems view.WIREs mechanisms of disease · 2021Review
- Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency.Pharmaceutics · 2021Article
- Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility.Molecular cell · 2019Article
- Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.Genes & development · 2019Article
- Altered ultradian cortisol rhythmicity as a potential neurobiologic substrate for chronic insomnia.Sleep medicine reviews · 2018Review
- TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network.BMC bioinformatics · 2017Article
- Ultradian glucocorticoid exposure directs gene-dependent and tissue-specific mRNA expression patterns in vivo.Molecular and cellular endocrinology · 2017Article
- Transcription factor oscillations in neural stem cells: Implications for accurate control of gene expression.Neurogenesis (Austin, Tex.) · 2017Review
- Dexamethasone Modulates Nonvisual Opsins, Glucocorticoid Receptor, and Clock Genes inBioMed research international · 2017Article
- Using Cox cluster processes to model latent pulse location patterns in hormone concentration data.Biostatistics (Oxford, England) · 2016Article
- Hippocampal Fast Glutamatergic Transmission Is Transiently Regulated by Corticosterone Pulsatility.PloS one · 2016Article
- An optimization formulation for characterization of pulsatile cortisol secretion.Frontiers in neuroscience · 2015Article
- Seasonal variation in cortisol biomarkers in Hispanic mothers living in an agricultural region.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2015Article
- Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor.Molecular and cellular endocrinology · 2013Review
- Translational applications of evaluating physiologic variability in human endotoxemia.Journal of clinical monitoring and computing · 2013Review
- Regulation of cortisol bioavailability--effects on hormone measurement and action.Nature reviews. Endocrinology · 2012Review
- Protein kinase C regulates late cell cycle-dependent gene expression.Molecular and cellular biology · 2012Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
contextCortisol is released in ultradian pulses. The biological relevance of the resulting fluctuating cortisol concentration has not been explored.
objectiveDetermination of the biological consequences of ultradian cortisol pulsatility.
designA novel flow through cell culture system was developed to deliver ultradian pulsed or continuous cortisol to cells. The effects of cortisol dynamics on cell proliferation and survival, and on gene expression were determined. In addition, effects on glucocorticoid receptor (GR) expression levels and phosphorylation, as a potential mediator, were measured.
resultsPulsatile cortisol caused a significant reduction in cell survival compared to continuous exposure of the same cumulative dose, due to increased apoptosis. Comprehensive analysis of the transcriptome response by microarray identified genes with a differential response to pulsatile versus continuous glucocorticoid delivery. These were confirmed with qRT-PCR. Several transcription factor binding sites were enriched in these differentially regulated target genes, including CCAAT-displacement protein (CDP). A CDP regulated reporter gene (MMTV-luc) was, as predicted, also differentially regulated by pulsatile compared to continuous cortisol delivery. Importantly there was no effect of cortisol delivery kinetics on either GR expression, or activation (GR phosphoSer(211)).
conclusionsCortisol oscillations exert important effects on target cell gene expression, and phenotype. This is not due to differences in cumulative cortisol exposure, or either expression, or activation of the GR. This suggests a novel means to regulate GR function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.